diff --git a/Makefile.am b/Makefile.am
index 9ce6f2ccd0262..b059d0c6f7d43 100644
--- a/Makefile.am
+++ b/Makefile.am
@@ -15,8 +15,6 @@ endif
 .PHONY: deploy FORCE
 .INTERMEDIATE: $(COVERAGE_INFO)
 
-export PYTHONPATH
-
 if BUILD_BITCOIN_LIBS
 pkgconfigdir = $(libdir)/pkgconfig
 pkgconfig_DATA = libdashconsensus.pc
diff --git a/configure.ac b/configure.ac
index ec5241933cd55..915dc8d49d720 100644
--- a/configure.ac
+++ b/configure.ac
@@ -127,8 +127,6 @@ AC_PATH_TOOL(DSYMUTIL, dsymutil)
 AC_PATH_PROG(DOXYGEN, doxygen)
 AM_CONDITIONAL([HAVE_DOXYGEN], [test -n "$DOXYGEN"])
 
-AC_ARG_VAR(PYTHONPATH, Augments the default search path for python module files)
-
 AC_ARG_ENABLE([wallet],
   [AS_HELP_STRING([--disable-wallet],
   [disable wallet (enabled by default)])],
diff --git a/depends/config.site.in b/depends/config.site.in
index 2721a25171955..26d5bcfcc2a44 100644
--- a/depends/config.site.in
+++ b/depends/config.site.in
@@ -97,7 +97,6 @@ fi
 if test -n "@CXX@" -a -z "${CXX}"; then
   CXX="@CXX@"
 fi
-PYTHONPATH="${depends_prefix}/native/lib/python3/dist-packages${PYTHONPATH:+${PATH_SEPARATOR}}${PYTHONPATH}"
 
 if test -n "@AR@"; then
   AR="@AR@"