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Incorrect annotations for translation regulator #5641

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ValWood opened this issue Feb 10, 2025 · 2 comments
Open

Incorrect annotations for translation regulator #5641

ValWood opened this issue Feb 10, 2025 · 2 comments
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@ValWood
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ValWood commented Feb 10, 2025

from geneontology/go-ontology#29089

ZFIN:ZDB-GENE-030131-8656 ribosomal protein L10 GO:0045182 UniProt NCBITaxon:7955 protein_coding_gene PMID:25316788|ZFIN:ZDB-PUB-141016-1
-> incorrect, not a translation regulator

UniProtKB:P46781 Small ribosomal subunit protein uS4 GO:0045182 UniProt NCBITaxon:9606 protein PMID:18420587
UniProtKB:P27635 Large ribosomal subunit protein uL16 GO:0045182 UniProt NCBITaxon:9606 protein PMID:26290468
UniProtKB:P62263 Small ribosomal subunit protein uS11 GO:0045182 UniProt NCBITaxon:9606 protein PMID:3683397

uORFS
these are not "translation regulators" (no functional product), but could be annotated to "regulation of translation, I guess"

PlasmoDB:PF3D7_1200610 VAR2CSA uORF GO:0045182 GeneDB NCBITaxon:36329 mRNA PMID:19119419
UniProtKB:C0HM02 PRKCH upstream open reading frame 2 GO:0045182 UniProt NCBITaxon:9606 protein PMID:19797084
UniProtKB:C0HM02 PRKCH upstream open reading frame 2 GO:0045182 UniProt NCBITaxon:9606 protein PMID:34593629
SGD:S000005828 CPA1 uORF GO:0045182 SGD NCBITaxon:559292 protein PMID:10608810

The above annotations came out of a review for the ticket linked above

UniProt @Antonialock (let me know if you would like me to do protein2GO disputes)
SGD @edwong57
PlasmoDB @uliboehme

@sramachand
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@ValWood @LeylaR @Antonialock
It looks like the rpl10 annotation for translational regulator activity comes from UniProt?

@ValWood
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ValWood commented Feb 10, 2025

OK, removed Zfin
v

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