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hallmark_DB.gmt
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HALLMARK_ADIPOGENESIS > Genes up-regulated during adipocyte differentiation (adipogenesis). ABCA1 ABCB8 ACAA2 ACADL ACADM ACADS ACLY ACO2 ACOX1 ADCY6 ADIG ADIPOQ ADIPOR2 AGPAT3 AGPAT6 AIFM1 AK2 ALDH2 ALDOA ANGPT1 ANGPTL4 ANKRD57 APLP2 APOE ARAF ARL4A ATL2 ATP1B3 ATP5O BAZ2A BCKDHA BCL2L13 BCL6 C3 CAT CCNG2 CD151 CD302 CD36 CDKN2C CHCHD10 CHUK CIDEA CMBL CMPK1 COL15A1 COL4A1 COQ3 COQ5 COQ9 COX6A1 COX7B COX8A CPT2 CRAT CS CYC1 CYP4B1 DBT DDT DECR1 DGAT1 DHCR7 DHRS7 DHRS7B DLAT DLD DNAJB9 DNAJC15 DRAM2 ECH1 ECHS1 ELMOD3 ELOVL6 ENPP2 EPHX2 ESRRA ESYT1 ETFB FABP4 FAH FAM73B FAM82A2 FZD4 G3BP2 GADD45A GBE1 GHITM GPAM GPD2 GPHN GPX3 GPX4 GRPEL1 HADH HIBCH HSPB8 IDH1 IDH3A IDH3G IFNGR1 IMMT ITGA7 ITIH5 ITSN1 JAGN1 LAMA4 LEP LIFR LIPE LPCAT3 LPL LTC4S MAP4K3 MCCC1 MDH2 ME1 MGLL MGST3 MOSC2 MRAP MRPL15 MTCH2 MYLK NDUFA5 NDUFAB1 NDUFB7 NDUFS3 NKIRAS1 NMT1 OBFC2A OMD ORM1 PDCD4 PEMT PEX14 PFKFB3 PFKL PGM1 PHLDB1 PHYH PIM3 PLIN2 POR PPARG PPM1B PPP1R15B PQLC3 PRDX3 PREB PTCD3 PTGER3 PTRF QDPR RAB34 REEP5 REEP6 RETN RETSAT RIOK3 RNF11 RREB1 RTN3 SAMM50 SCARB1 SCP2 SDHB SDHC SDPR SLC19A1 SLC1A5 SLC25A1 SLC25A10 SLC27A1 SLC5A6 SNCG SOD1 SORBS1 SPARCL1 SQRDL SSPN STAT5A STOM SUCLG1 SULT1A1 TALDO1 TANK TKT TOB1 TST UBC UBQLN1 UCK1 UCP2 UQCR10 UQCR11 UQCRC1 UQCRQ VEGFB YWHAG
HALLMARK_ALLOGRAFT_REJECTION > Genes up-regulated during transplant rejection. AARS ABCE1 ABI1 ACHE ACVR2A AKT1 APBB1 B2M BCAT1 BCL10 BCL3 BRCA1 C2 CAPG CARTPT CCL11 CCL13 CCL19 CCL2 CCL22 CCL4 CCL5 CCL7 CCND2 CCND3 CCR1 CCR2 CCR5 CD1D CD2 CD247 CD28 CD3D CD3E CD3G CD4 CD40 CD40LG CD47 CD7 CD74 CD79A CD80 CD86 CD8A CD8B CD96 CDKN2A CFP CRTAM CSF1 CSK CTSS CXCL13 CXCL9 CXCR3 DARS DEGS1 DYRK3 EGFR EIF3A EIF3D EIF3J EIF4G3 EIF5A ELANE ELF4 EREG ETS1 F2 F2R FAS FASLG FCGR2B FGR FLNA FYB GALNT1 GBP2 GCNT1 GLMN GPR65 GZMA GZMB HCLS1 HDAC9 HIF1A HLA-A HLA-DMA HLA-DMB HLA-DOA HLA-DOB HLA-DQA1 HLA-DRA HLA-E HLA-G ICAM1 ICOSLG IFNAR2 IFNG IFNGR1 IFNGR2 IGSF6 IKBKB IL10 IL11 IL12A IL12B IL12RB1 IL13 IL15 IL16 IL18 IL18RAP IL1B IL2 IL27RA IL2RA IL2RB IL2RG IL4 IL4R IL6 IL7 IL9 INHBA INHBB IRF4 IRF7 IRF8 ITGAL ITGB2 ITK JAK2 KLRD1 KRT1 LCK LCP2 LIF LTB LY75 LY86 LYN MAP3K7 MAP4K1 MBL2 MMP9 MRPL3 MTIF2 NCF4 NCK1 NCR1 NLRP3 NME1 NOS2 NPM1 PF4 PRF1 PRKCB PRKCG PSMB10 PTPN6 PTPRC RARS RIPK2 RPL39 RPL3L RPL9 RPS19 RPS3A RPS9 SIT1 SOCS1 SOCS5 SPI1 SRGN ST8SIA4 STAB1 STAT1 STAT4 TAP1 TAP2 TAPBP TGFB1 TGFB2 THY1 TIMP1 TLR1 TLR2 TLR3 TLR6 TNF TPD52 TRAF2 TRAT1 UBE2D1 UBE2N WARS WAS ZAP70
HALLMARK_ANDROGEN_RESPONSE > Genes defining response to androgens. ABCC4 ABHD2 ACSL3 ACTN1 ADAMTS1 ADRM1 AKAP12 AKT1 ALDH1A3 ANKH APPBP2 ARID5B AZGP1 B2M B4GALT1 BMPR1B CAMKK2 CCND1 CCND3 CDC14B CDK6 CENPN DBI DHCR24 DNAJB9 ELK4 ELL2 ELOVL5 FADS1 FKBP5 GNAI3 GPD1L GSR GUCY1A3 H1F0 HERC3 HMGCR HMGCS1 HOMER2 HPGD HSD17B14 IDI1 INPP4B INSIG1 IQGAP2 ITGAV KLK2 KLK3 KRT19 KRT8 LIFR LMAN1 MAF MAK MAP7 MERTK MYL12A NCOA4 NDRG1 NGLY1 NKX3-1 PA2G4 PDLIM5 PGM3 PIAS1 PMEPA1 PPAP2A PTK2B PTPN21 RAB4A RPS6KA3 RRP12 SAT1 SCD SEC24D SEPP1 SGK1 SLC26A2 SLC38A2 SMS SORD SPCS3 SPDEF SRF SRP19 STEAP4 STK39 TARP TMEM50A TMPRSS2 TNFAIP8 TPD52 TSC22D1 UAP1 UBE2I UBE2J1 VAPA XRCC5 XRCC6 ZBTB10 ZMIZ1
HALLMARK_ANGIOGENESIS > Genes up-regulated during formation of blood vessels (angiogenesis). APOH APP CCND2 COL3A1 COL5A2 CXCL6 FGFR1 FSTL1 ITGAV JAG1 JAG2 KCNJ8 LPL LRPAP1 LUM MSX1 NRP1 OLR1 PDGFA PF4 PGLYRP1 POSTN PRG2 PTK2 S100A4 SERPINA5 SLCO2A1 SPP1 STC1 THBD TIMP1 TNFRSF21 VAV2 VCAN VEGFA VTN
HALLMARK_APICAL_JUNCTION > Genes encoding components of apical junction complex. ACTA1 ACTB ACTC1 ACTG1 ACTG2 ACTN1 ACTN2 ACTN3 ACTN4 ADAM15 ADAM23 ADAM9 ADAMTS5 ADRA1B AKT2 AKT3 ALOX15B AMH AMIGO1 AMIGO2 ARHGEF6 ARPC2 ATP1A3 B4GALT1 BAIAP2 BMP1 CADM2 CADM3 CALB2 CAP1 CD209 CD274 CD276 CD34 CD86 CD99 CDH1 CDH11 CDH15 CDH3 CDH4 CDH6 CDH8 CDK8 CDSN CERCAM CLDN11 CLDN14 CLDN15 CLDN18 CLDN19 CLDN4 CLDN5 CLDN6 CLDN7 CLDN8 CLDN9 CNN2 CNTN1 COL16A1 COL17A1 COL9A1 CRAT CRB3 CTNNA1 CTNND1 CX3CL1 DHX16 DLG1 DMP1 DSC1 DSC3 EGFR EPB41L2 EVL EXOC4 FBN1 FLNC FSCN1 FYB GAMT GNAI1 GNAI2 GRB7 GTF2F1 HADH HRAS ICAM1 ICAM2 ICAM4 ICAM5 IKBKG INPPL1 INSIG1 IRS1 ITGA10 ITGA2 ITGA3 ITGA9 ITGB1 ITGB4 JAM3 JUP KCNH2 KRT31 LAMA3 LAMB3 LAMC2 LAYN LDLRAP1 LIMA1 MADCAM1 MAP4K2 MAPK11 MAPK13 MAPK14 MDK MMP2 MMP9 MPP5 MPZL1 MPZL2 MSN MVD MYH10 MYH9 MYL12B MYL9 NEGR1 NEXN NF1 NF2 NFASC NLGN2 NLGN3 NRAP NRTN NRXN2 PARD6G PARVA PBX2 PCDH1 PDZD3 PECAM1 PFN1 PIK3CB PIK3R3 PKD1 PLCG1 PPP2R2C PTEN PTK2 PTPRC PVRL1 PVRL2 PVRL3 PVRL4 RAC2 RASA1 RHOF RRAS RSU1 SDC3 SGCE SHC1 SHROOM2 SIRPA SKAP2 SLC30A3 SLIT2 SORBS3 SPEG SRC STX4 SYK SYMPK TAOK2 TGFBI THBS3 THY1 TIAL1 TJP1 TMEM8B TNFRSF11B TRAF1 TRO TSC1 TSPAN4 TUBG1 VASP VAV2 VCAM1 VCAN VCL VWF WASL WNK4 YWHAH ZAK ZYX
HALLMARK_APICAL_SURFACE > Genes encoding proteins over-represented on the apical surface of epithelial cells, e.g., important for cell polarity (apical area). ADAM10 ADIPOR2 AFAP1L2 AIM1 AKAP7 APP ATP6V0A4 ATP8B1 B4GALT1 BRCA1 CD160 CROCC CX3CL1 DCBLD2 EFNA5 EPHB4 FLOT2 GAS1 GATA3 GHRL GSTM3 HSPB1 IL2RB IL2RG LYN LYPD3 MAL MDGA1 NCOA6 NTNG1 PCSK9 PKHD1 PLAUR RHCG RTN4RL1 SCUBE1 SHROOM2 SLC22A12 SLC2A4 SLC34A3 SRPX SULF2 THY1 TMEM8B
HALLMARK_APOPTOSIS > Genes mediating programmed cell death (apoptosis) by activation of caspases. ADD1 AIFM3 ANKH ANXA1 APP ATF3 AVPR1A BAX BCAP31 BCL10 BCL2L1 BCL2L10 BCL2L11 BCL2L2 BGN BID BIK BIRC3 BMF BMP2 BNIP3L BRCA1 BTG2 BTG3 CASP1 CASP2 CASP3 CASP4 CASP6 CASP7 CASP8 CASP9 CAV1 CCNA1 CCND1 CCND2 CD14 CD2 CD38 CD44 CD69 CDC25B CDK2 CDKN1A CDKN1B CFLAR CLU CREBBP CTH CTNNB1 CYLD DAP DAP3 DCN DDIT3 DFFA DIABLO DNAJA1 DNAJC3 DNM1L DPYD EBP EGR3 EMP1 ENO2 ERBB2 ERBB3 EREG ETF1 F2 F2R FAS FASLG FDXR FEZ1 GADD45A GADD45B GCH1 GNA15 GPX1 GPX3 GPX4 GSN GSR GSTM1 GUCY2D H1F0 HGF HMGB2 HMOX1 HSPB1 IER3 IFITM3 IFNB1 IFNGR1 IGF2R IGFBP6 IL18 IL1A IL1B IL6 IRF1 ISG20 JUN KRT18 LEF1 LGALS3 LMNA LPPR4 LUM MADD MCL1 MGMT MMP2 NEDD9 NEFH PAK1 PDCD4 PDGFRB PEA15 PLAT PLCB2 PMAIP1 PPP2R5B PPP3R1 PPT1 PRF1 PSEN1 PSEN2 PTK2 RARA RELA RETSAT RHOB RHOT2 RNASEL ROCK1 SAT1 SATB1 SC5DL SLC20A1 SMAD7 SOD1 SOD2 SPTAN1 SQSTM1 TAP1 TGFB2 TGFBR3 TIMP1 TIMP2 TIMP3 TNF TNFRSF12A TNFSF10 TOP2A TSPO TXNIP VDAC2 WEE1 XIAP
HALLMARK_BILE_ACID_METABOLISM > Genes involve in metabolism of bile acids and salts. ABCA1 ABCA2 ABCA3 ABCA4 ABCA5 ABCA6 ABCA8 ABCA9 ABCD1 ABCD2 ABCD3 ABCG4 ABCG8 ACSL1 ACSL5 AGXT AKR1D1 ALDH1A1 ALDH8A1 ALDH9A1 AMACR APOA1 AQP9 AR ATXN1 BBOX1 BCAR3 BMP6 CAT CH25H CROT CYP27A1 CYP39A1 CYP46A1 CYP7A1 CYP7B1 CYP8B1 DHCR24 DIO1 DIO2 EFHC1 EPHX2 FADS1 FADS2 FDXR GC GCLM GNMT GNPAT GSTK1 HACL1 HAO1 HSD17B11 HSD17B4 HSD17B6 HSD3B1 HSD3B7 IDH1 IDH2 IDI1 ISOC1 KLF1 LCK LIPE LONP2 MLYCD NEDD4 NPC1 NR0B2 NR1H4 NR1I2 NR3C2 NUDT12 OPTN PAOX PECR PEX1 PEX11A PEX11G PEX12 PEX13 PEX16 PEX19 PEX26 PEX6 PEX7 PFKM PHYH PIPOX PNPLA8 PRDX5 PXMP2 RBP1 RETSAT RXRA RXRG SCP2 SERPINA6 SLC22A18 SLC23A1 SLC23A2 SLC27A2 SLC27A5 SLC29A1 SLC35B2 SLCO1A2 SOAT2 SOD1 SULT1B1 SULT2B1 TFCP2L1 TTR
HALLMARK_CHOLESTEROL_HOMEOSTASIS > Genes involved in cholesterol homeostasis. ABCA2 ACAT2 ACSS2 ACTG1 ADH4 ALCAM ALDOC ANTXR2 ANXA13 ANXA5 ATF3 ATF5 ATXN2 AVPR1A CBS CD9 CHKA CLU CPEB2 CTNNB1 CXCL16 CYP51A1 DHCR7 EBP ECH1 ERRFI1 ETHE1 FABP5 FADS2 FAM129A FASN FBXO6 FDFT1 FDPS GLDC GNAI1 GPX8 GSTM2 GUSB HMGCR HMGCS1 HSD17B7 IDI1 JAG1 LDLR LGALS3 LGMN LPL LSS MAL2 MVD MVK NFIL3 NSDHL PCYT2 PDK3 PLAUR PLSCR1 PMVK PNRC1 PPARG S100A11 SC5DL SCD SEMA3B SQLE SREBF2 STARD4 STX5 TM7SF2 TMEM97 TNFRSF12A TP53INP1 TRIB3
HALLMARK_COAGULATION > Genes encoding components of blood coagulation system; also up-regulated in platelets. A2M ACOX2 ADAM9 ANG ANXA1 APOA1 APOC1 APOC2 APOC3 ARF4 BMP1 C1QA C1R C1S C2 C3 C8A C8B C8G C9 CAPN2 CAPN5 CASP9 CD9 CFB CFD CFH CFI CLU COMP CPB2 CPN1 CRIP2 CSRP1 CTSB CTSE CTSH CTSK CTSL2 CTSO DCT DPP4 DUSP14 DUSP6 F10 F11 F12 F13B F2 F2RL2 F3 F8 F9 FBN1 FGA FGG FN1 FURIN FYN GDA GNB2 GNG12 GP1BA GP9 GSN HMGCS2 HNF4A HPN HRG HTRA1 ISCU ITGA2 ITGB3 ITIH1 KLF7 KLK8 KLKB1 LAMP2 LEFTY2 LGMN LRP1 LTA4H MAFF MASP2 MBL2 MEP1A MMP1 MMP10 MMP11 MMP14 MMP15 MMP2 MMP3 MMP7 MMP8 MMP9 MSRB2 MST1 OLR1 P2RY1 PDGFB PECAM1 PEF1 PF4 PGCP PLAT PLAU PLEK PLG PREP PROC PROS1 PROZ PRSS23 RABIF RAC1 RAPGEF3 RGN S100A1 S100A13 SERPINA1 SERPINB2 SERPINC1 SERPINE1 SERPING1 SH2B2 SIRT2 SPARC TF TFPI2 THBD THBS1 TIMP1 TIMP3 TMPRSS6 USP11 VWF WDR1
HALLMARK_COMPLEMENT > Genes encoding components of the complement system, which is part of the innate immune system. ACTN2 ADAM9 ADRA2B AKAP10 ANG ANXA5 APOA4 APOBEC3F APOBEC3G APOC1 ATOX1 BRPF3 C1QA C1QC C1R C1S C2 C3 C4BPB C9 CA2 CALM1 CALM3 CASP1 CASP10 CASP3 CASP4 CASP5 CASP7 CASP9 CBLB CCL5 CD36 CD40LG CD46 CD55 CD59 CDA CDH13 CDK5R1 CEBPB CFB CFH CLU COL4A2 CP CPM CR1 CR2 CSRP1 CTSB CTSC CTSD CTSH CTSL1 CTSL2 CTSO CTSS CXCL1 DGKG DGKH DOCK10 DOCK4 DOCK9 DPP4 DUSP5 DUSP6 DYRK2 EHD1 ERAP2 F10 F2 F3 F5 F7 F8 FCER1G FCN1 FDX1 FN1 FYN GATA3 GCA GMFB GNAI2 GNAI3 GNB2 GNB4 GNG2 GNGT2 GP1BA GP9 GPD2 GRB2 GZMA GZMB GZMK HNF4A HPCAL4 HSPA1A HSPA5 IL6 IRF1 IRF2 IRF7 ITGAM ITIH1 JAK2 KCNIP2 KCNIP3 KIF2A KLK1 KLKB1 KYNU L3MBTL4 LAMP2 LAP3 LCK LCP2 LGALS3 LGMN LIPA LRP1 LTA4H LTF LYN MAFF ME1 MMP12 MMP13 MMP14 MMP15 MMP8 MT3 NOTCH4 OLR1 PCLO PCSK9 PDGFB PDP1 PFN1 PGCP PHEX PIK3CA PIK3CG PIK3R5 PIM1 PLA2G4A PLA2G7 PLAT PLAUR PLEK PLG PLSCR1 PPP2CB PPP4C PRCP PRDM4 PREP PRKCD PRSS3 PRSS36 PSEN1 PSMB9 RABIF RAF1 RASGRP1 RCE1 RHOG RNF4 S100A12 S100A13 S100A9 SCG3 SEPX1 SERPINA1 SERPINB2 SERPINC1 SERPINE1 SERPING1 SH2B3 SIRT6 SPOCK2 SRC STX4 TFPI2 TIMP1 TIMP2 TMPRSS6 TNFAIP3 USP14 USP15 USP16 USP8 VCPIP1 WAS XPNPEP1 ZEB1 ZFPM2 ZFYVE20
HALLMARK_DNA_REPAIR > Genes involved in DNA repair. AAAS ADA ADCY6 ADRM1 AK1 AK3 APRT ARL6IP1 BCAM BCAP31 BOLA2 BRF2 BRP44 CANT1 CCNO CDA CETN2 CLP1 CMPK2 COBRA1 COX17 CSTF3 DAD1 DCTN4 DDB1 DDB2 DFNA5 DGCR8 DGUOK DUT EDF1 EIF1B EIF2C4 ELL ERCC1 ERCC2 ERCC3 ERCC4 ERCC5 ERCC8 FEN1 GMPR2 GPX4 GTF2A2 GTF2B GTF2F1 GTF2H1 GTF2H3 GTF2H5 GTF3C5 GUK1 HCLS1 HPRT1 IMPDH2 ITPA LIG1 MPG MRPL40 NCBP2 NFX1 NME1 NME3 NME4 NPR2 NT5C NT5C3 NUDT21 NUDT9 PCNA PDE4B PDE6G PNP POLA1 POLA2 POLB POLD1 POLD3 POLD4 POLE4 POLH POLL POLR1C POLR1D POLR2A POLR2C POLR2D POLR2E POLR2F POLR2G POLR2H POLR2I POLR2J POLR2K POLR3C POLR3GL POM121 PRIM1 RAD51 RAD52 RAE1 RALA RBX1 RDBP REV3L RFC2 RFC3 RFC4 RFC5 RNMT RPA2 RPA3 RRM2B SAC3D1 SDCBP SEC61A1 SF3A3 SMAD5 SNAPC4 SNAPC5 SRSF6 SSRP1 STX3 SUPT4H1 SUPT5H SURF1 TAF10 TAF12 TAF13 TAF1C TAF6 TAF9 TARBP2 TCEB3 TH1L THOC4 TK2 TMED2 TP53 TSG101 TYMS UMPS UPF3B USP11 VPS28 VPS37B VPS37D XPC ZNF707 ZNRD1 ZWINT
HALLMARK_E2F_TARGETS > Genes encoding cell cycle related targets of E2F transcription factors. AK2 ANP32E ASF1A ASF1B ATAD2 AURKA AURKB BARD1 BIRC5 BRCA1 BRCA2 BRMS1L BUB1B CBX5 CCNB2 CCNE1 CCP110 CDC20 CDC25A CDC25B CDCA3 CDCA8 CDK1 CDK4 CDKN1A CDKN1B CDKN2A CDKN2C CDKN3 CENPE CENPM CHEK1 CHEK2 CIT CKS1B CKS2 CSE1L CTCF CTPS DCK DCLRE1B DCTPP1 DDX39A DEK DEPDC1 DIAPH3 DLGAP5 DNMT1 DONSON DSCC1 DUT E2F8 EED EIF2S1 ESPL1 EXOSC8 EZH2 GINS1 GINS3 GINS4 GSPT1 H2AFX H2AFZ HELLS HMGA1 HMGB2 HMGB3 HMMR HN1 HNRNPD HUS1 ILF3 ING3 IPO7 KIF18B KIF22 KIF2C KIF4A KPNA2 LBR LIG1 LMNB1 LUC7L3 LYAR MAD2L1 MCM2 MCM3 MCM4 MCM5 MCM6 MCM7 MELK MKI67 MLH1 MMS22L MRE11A MSH2 MTHFD2 MXD3 MYBL2 MYC NAA38 NAP1L1 NASP NBN NCAPD2 NME1 NOLC1 NOP56 NUDT21 NUP107 NUP153 NUP205 ORC2 ORC6 PA2G4 PAICS PAN2 PCNA PDS5B PHF5A PLK1 PLK4 PMS2 PNN POLA2 POLD1 POLD2 POLD3 POLE POLE4 POP7 PPM1D PPP1R8 PRDX4 PRIM2 PRKDC PRPS1 PSIP1 PSMC3IP PTTG1 RACGAP1 RAD1 RAD21 RAD50 RAD51AP1 RAD51C RAN RANBP1 RBBP7 RFC1 RFC2 RFC3 RNASEH2A RPA1 RPA2 RPA3 RQCD1 RRM2 SHMT1 SLBP SMC1A SMC3 SMC4 SMC6 SNRPB SPAG5 SPC24 SPC25 SRSF1 SRSF2 SSRP1 STAG1 STMN1 SUV39H1 SYNCRIP TACC3 TBRG4 TCF19 TFRC TIMELESS TIPIN TK1 TMPO TOP2A TP53 TRA2B TRIP13 TUBB TUBG1 UBE2S UBE2T UBR7 UNG USP1 WDR90 WEE1 XPO1 XRCC6 ZW10
HALLMARK_EPITHELIAL_MESENCHYMAL_TRANSITION > Genes defining epithelial-mesenchymal transition, as in wound healing, fibrosis and metastasis. ABI3BP ACTA2 ADAM12 ANPEP APLP1 AREG BASP1 BDNF BGN BMP1 CADM1 CALD1 CALU CAP2 CAPG CD44 CD59 CDH11 CDH2 CDH6 COL11A1 COL12A1 COL16A1 COL1A1 COL1A2 COL3A1 COL4A1 COL4A2 COL5A1 COL5A2 COL5A3 COL6A2 COL6A3 COL7A1 COL8A2 COMP COPA CRLF1 CTGF CTHRC1 CXCL1 CXCL12 CXCL6 CYR61 DAB2 DCN DKK1 DPYSL3 DST ECM1 ECM2 EDIL3 EFEMP2 ELN EMP3 ENO2 FAP FAS FBLN1 FBLN2 FBLN5 FBN1 FBN2 FERMT2 FGF2 FLNA FMOD FN1 FOXC2 FSTL1 FSTL3 FUCA1 FZD8 GADD45A GADD45B GAS1 GEM GJA1 GLIPR1 GLT25D1 GPC1 GPX7 GREM1 HTRA1 ID2 IGFBP2 IGFBP3 IGFBP4 IL15 IL32 IL6 IL8 INHBA ITGA2 ITGA5 ITGAV ITGB1 ITGB3 ITGB5 JUN LAMA1 LAMA2 LAMA3 LAMC1 LAMC2 LEPRE1 LGALS1 LOX LOXL1 LOXL2 LRP1 LRRC15 LUM MAGEE1 MATN2 MATN3 MCM7 MEST MFAP5 MGP MMP1 MMP14 MMP2 MMP3 MSX1 MXRA5 MYL9 MYLK NID2 NNMT NOTCH2 NT5E NTM OXTR PCOLCE PCOLCE2 PDGFRB PDLIM4 PFN2 PLAUR PLOD1 PLOD2 PLOD3 PMEPA1 PMP22 POSTN PPIB PRRX1 PRSS2 PTHLH PTX3 PVR QSOX1 RGS4 RHOB SAT1 SCG2 SDC1 SDC4 SERPINE1 SERPINE2 SERPINH1 SFRP1 SFRP4 SGCB SGCD SGCG SLC6A8 SLIT2 SLIT3 SNAI2 SNTB1 SPARC SPOCK1 SPP1 TAGLN TFPI2 TGFB1 TGFBI TGFBR3 TGM2 THBS1 THBS2 THY1 TIMP1 TIMP3 TNC TNFAIP3 TNFRSF11B TNFRSF12A TPM1 TPM2 TPM4 VCAM1 VCAN VEGFA VEGFC VIM WIPF1 WNT5A
HALLMARK_ESTROGEN_RESPONSE_EARLY > Genes defining early response to estrogen. ABAT ABCA3 ABHD2 ABLIM1 ADCY1 ADCY9 ADD3 AFF1 AKAP1 ALDH3B1 AMFR ANXA9 AQP3 AR AREG ARL3 ASB13 B4GALT1 BAG1 BCL11B BCL2 BHLHE40 BLVRB CA12 CALB2 CALCR CANT1 CBFA2T3 CCND1 CD44 CELSR1 CELSR2 CHPT1 CISH CLDN7 CLIC3 CXCL12 CYP26B1 DEPTOR DHCR7 DHRS2 DHRS3 DLC1 DYNLT3 EGR3 ELF1 ELF3 ELOVL2 ELOVL5 ENDOD1 ESRP2 FAIM3 FAM102A FAM134B FAM63A FARP1 FASN FDFT1 FHL2 FKBP4 FKBP5 FLNB FOS FOXC1 FRK GAB2 GFRA1 GJA1 GLA GREB1 HES1 HR HSPB8 IGF1R IGFBP4 IL17RB IL6ST INHBB INPP5F ISG20L2 ITPK1 JAK2 KAZN KCNK15 KCNK5 KDM4B KLF10 KLF4 KLK10 KRT13 KRT15 KRT18 KRT19 KRT8 LAD1 LRIG1 MAPT MAST4 MED13L MED24 MICB MLPH MPPED2 MREG MSMB MUC1 MYB MYBBP1A MYBL1 MYC MYOF NADSYN1 NAV2 NBL1 NCOR2 NPY1R NRIP1 NXT1 OLFM1 OLFML3 OPN3 OVOL2 P2RY2 PAPSS2 PDLIM3 PDZK1 PEX11A PGR PLA2G16 PMAIP1 PODXL PPIF PRSS23 PTGES RAB17 RAB31 RAPGEFL1 RARA RASGRP1 RBBP8 REEP1 RET RHOBTB3 RHOD RPS6KA2 RRP12 SCARB1 SCNN1A SEC14L2 SEMA3B SFN SH3BP5 SIAH2 SLC16A1 SLC19A2 SLC1A1 SLC1A4 SLC22A5 SLC24A3 SLC26A2 SLC27A2 SLC2A1 SLC37A1 SLC39A6 SLC7A2 SLC7A5 SLC9A3R1 SNX24 SOX3 STC2 SULT2B1 SVIL SYBU SYNGR1 SYT12 TBC1D30 TFAP2C TFF1 TFF3 TGIF2 TGM2 THSD4 TIAM1 TIPARP TJP3 TMEM164 TMPRSS3 TOB1 TPBG TPD52L1 TSKU TTC39A TUBB2B UGCG UNC119 WFS1 WISP2 WWC1 XBP1 ZNF185
HALLMARK_ESTROGEN_RESPONSE_LATE > Genes defining late response to estrogen. ABCA3 ABHD2 ACOX2 ADD3 AFF1 AGR2 ALDH3A2 ALDH3B1 AMFR ANXA9 AREG ARL3 ASCL1 ASS1 ATP2B4 BAG1 BATF BCL2 BLVRB BTG3 CA12 CA2 CACNA2D2 CALCR CAV1 CCNA1 CCND1 CD44 CD9 CDC20 CDC6 CDH1 CELSR2 CHPT1 CHST8 CISH CKB CLIC3 COX6C CPE CXCL12 CXCL14 CYP26B1 CYP4F11 DCXR DHCR7 DHRS2 DLG5 DNAJC1 DNAJC12 DUSP2 DYNLT3 EGR3 ELOVL5 EMP2 ETFB FABP5 FAM102A FARP1 FDFT1 FGFR3 FKBP4 FKBP5 FLNB FOS FOXC1 FRK GAL GALE GINS2 GJB3 GLA GPER HMGCS2 HOMER2 HPRT1 HR HSPA4L HSPB8 ID2 IDH2 IGFBP4 IGSF1 IL17RB IL6ST IMPA2 ISG20 ITPK1 JAK1 JAK2 KCNK5 KIF20A KLF4 KLK10 KLK11 KRT13 KRT19 LAMC2 LARGE LLGL2 LSR LTF MAPK13 MAPT MDK MEST METTL3 MICB MOCS2 MYB MYOF NAB2 NBL1 NCOR2 NMU NPY1R NRIP1 NXT1 OLFM1 OPN3 OVOL2 PAPSS2 PCP4 PDCD4 PDLIM3 PDZK1 PERP PGR PKP3 PLA2G16 PLAC1 PLK4 PLXNB1 PPIF PRKAR2B PRLR PRSS23 PTGER3 PTGES PTPN6 RAB31 RABEP1 RAPGEFL1 RBBP8 RET RNASEH2A RPS6KA2 S100A9 SCARB1 SCNN1A SCUBE2 SEMA3B SERPINA1 SERPINA3 SERPINA5 SFN SGK1 SIAH2 SLC16A1 SLC1A4 SLC22A5 SLC24A3 SLC26A2 SLC27A2 SLC29A1 SLC2A8 SLC7A5 SLC9A3R1 SNX10 SORD SOX3 ST14 ST6GALNAC2 STIL SULT2B1 TFAP2C TFF1 TFF3 TFPI2 TH TIAM1 TJP3 TMPRSS3 TNNC1 TOB1 TOP2A TPBG TPD52L1 TPSAB1 TRIM29 TSPAN13 TST TSTA3 UGDH UNC13B WFS1 WISP2 XBP1 XRCC3 ZFP36
HALLMARK_FATTY_ACID_METABOLISM > Genes encoding proteins involved in metabolism of fatty acids. AADAT ACAA1 ACAA2 ACADL ACADM ACADS ACADVL ACAT2 ACO2 ACOT2 ACOT8 ACOX1 ACSL1 ACSL4 ACSL5 ACSM3 ACSS1 ADH1C ADH7 ADIPOR2 ADSL ALAD ALDH1A1 ALDH3A1 ALDH3A2 ALDH9A1 ALDOA AOC3 APEX1 AQP7 AUH BCKDHB BLVRA BMPR1B BPHL CA2 CA4 CA6 CBR1 CBR3 CCDC58 CD1D CD36 CEL CIDEA CPOX CPT1A CPT2 CRAT CRYZ CYP1A1 CYP4A11 CYP4A22 D2HGDH DECR1 DHCR24 DLD DLST ECH1 ECHS1 ECI1 ECI2 EHHADH ELOVL5 ENO2 ENO3 EPHX1 ERP29 ETFDH FABP1 FABP2 FASN FH FMO1 G0S2 GABARAPL1 GAD2 GAPDHS GCDH GLUL GPD1 GPD2 GRHPR GSTZ1 H2AFZ HADH HADHB HAO2 HCCS HIBCH HMGCL HMGCS1 HMGCS2 HPGD HSD17B10 HSD17B11 HSD17B4 HSD17B7 HSDL2 HSP90AA1 HSPH1 IDH1 IDH3B IDH3G IDI1 IL4I1 INMT LDHA LGALS1 LTC4S MAOA MCEE MDH1 MDH2 ME1 METAP1 MGLL MIF MLYCD NBN NCAPH2 NSDHL NTHL1 ODC1 OSTC PCBD1 PDHA1 PDHB PPARA PRDX6 PSME1 PTPRG PTS RAP1GDS1 RDH11 RDH16 REEP6 RETSAT S100A10 SDHA SDHC SDHD SERINC1 SETD8 SLC22A5 SMS SUCLA2 SUCLG1 SUCLG2 TDO2 TP53INP2 UBE2L6 UGDH UROD UROS VNN1 XIST YWHAH
HALLMARK_G2M_CHECKPOINT > Genes involved in the G2/M checkpoint, as in progression through the cell division cycle. ABL1 AMD1 ARID4A ATF5 ATRX AURKA AURKB BARD1 BCL3 BIRC5 BRCA2 BUB1 BUB3 CASC5 CASP8AP2 CBX1 CCNA2 CCNB2 CCND1 CCNF CCNT1 CDC20 CDC25A CDC25B CDC27 CDC45 CDC6 CDC7 CDK1 CDK4 CDKN1B CDKN2C CDKN3 CENPA CENPE CENPF CHAF1A CHEK1 CHMP1A CKS1B CKS2 CTCF CUL1 CUL3 CUL4A CUL5 DBF4 DDX39A DKC1 DMD DR1 DTYMK E2F1 E2F2 E2F3 E2F4 EFNA5 EGF ESPL1 EWSR1 EXO1 EZH2 FANCC FBXO5 FOXN3 G3BP1 GINS2 GSPT1 H2AFV H2AFX H2AFZ HIF1A HIRA HIST1H2BK HMGA1 HMGB3 HMGN2 HMMR HN1 HNRNPD HNRNPU HOXC10 HSPA8 HUS1 ILF3 INCENP KATNA1 KIF11 KIF15 KIF20B KIF22 KIF23 KIF2C KIF4A KIF5B KPNA2 KPNB1 LBR LIG3 LMNB1 MAD2L1 MAPK14 MARCKS MCM2 MCM3 MCM5 MCM6 MEIS1 MEIS2 MKI67 MNAT1 MT2A MTF2 MYBL2 MYC NASP NCL NDC80 NEK2 NOLC1 NOTCH2 NUMA1 NUP50 NUP98 NUSAP1 ODC1 ODF2 ORC5 ORC6 PAFAH1B1 PAPD7 PBK PDS5B PLK1 PLK4 PML POLA2 POLE POLQ PRC1 PRIM2 PRMT5 PRPF4B PTTG1 PTTG3P PURA RACGAP1 RAD21 RAD23B RAD54L RASAL2 RBL1 RBM14 RPA2 RPS6KA5 SAP30 SETD8 SFPQ SLC12A2 SLC38A1 SLC7A1 SLC7A5 SMAD3 SMARCC1 SMC1A SMC2 SMC4 SNRPD1 SQLE SRSF1 SRSF10 SRSF2 SS18 STAG1 STIL STMN1 SUV39H1 SYNCRIP TACC3 TFDP1 TGFB1 TLE3 TMPO TNPO2 TOP1 TOP2A TPX2 TRA2B TRAIP TROAP TTK UBE2C UBE2S UCK2 UPF1 WHSC1 WRN XPO1 YTHDC1 ZAK
HALLMARK_GLYCOLYSIS > Genes encoding proteins involved in glycolysis and gluconeogenesis. ABCB6 ADORA2B AGL AGRN AK3 AK4 AKR1A1 ALDH7A1 ALDH9A1 ALDOA ALDOB ALG1 ANG ANGPTL4 ANKZF1 ARPP19 ARTN AURKA B3GALT6 B3GAT1 B3GAT3 B3GNT3 B4GALT1 B4GALT2 B4GALT4 B4GALT7 BIK BPNT1 CACNA1H CAPN5 CASP6 CD44 CDK1 CENPA CHPF CHPF2 CHST1 CHST12 CHST2 CHST4 CHST6 CITED2 CLDN3 CLDN9 CLN6 COG2 COL5A1 COPB2 CTH CXCR4 CYB5A DCN DDIT4 DEPDC1 DLD DPYSL4 DSC2 ECD EFNA3 EGFR EGLN3 ELF3 ENO1 ENO2 ERO1L EXT1 EXT2 FAM162A FBP2 FKBP4 FUT8 G6PD GAL3ST1 GALE GALK1 GALK2 GAPDHS GCLC GFPT1 GLCE GLRX GMPPA GMPPB GNE GNPDA1 GOT1 GOT2 GPC1 GPC3 GPC4 GPR87 GUSB GYS1 GYS2 HAX1 HDLBP HK2 HMMR HOMER1 HS2ST1 HS6ST2 HSPA5 IDH1 IDUA IER3 IGFBP3 IL13RA1 IRS2 ISG20 KDELR3 KIF20A KIF2A LCT LDHA LDHC LHPP LHX9 MDH1 MDH2 ME1 ME2 MED24 MERTK MET MIF MIOX MPI MXI1 NANP NASP NDST3 NDUFV3 NOL3 NSDHL NT5E P4HA1 P4HA2 PAM PAXIP1 PC PDK3 PFKFB1 PFKP PGAM1 PGAM2 PGK1 PGLS PGM2 PHKA2 PKM2 PKP2 PLOD1 PLOD2 PMM2 POLR3K PPFIA4 PPIA PPP2CB PRPS1 PSMC4 PYGB PYGL QSOX1 RARS RBCK1 RPE RRAGD SAP30 SDC1 SDC2 SDC3 SDHC SLC16A3 SLC25A10 SLC25A13 SLC35A3 SLC37A4 SOD1 SOX9 SPAG4 SRD5A3 STC1 STC2 STMN1 TALDO1 TFF3 TGFA TGFBI TKTL1 TPBG TPI1 TPST1 TSTA3 TXN UGP2 VCAN VEGFA VLDLR XYLT2 ZNF292
HALLMARK_HEDGEHOG_SIGNALING > Genes up-regulated by activation of hedgehog signaling. ACHE AMOT CDK5R1 CDK6 CELSR1 CNTFR CRMP1 DPYSL2 ETS2 GLI1 GPR56 HEY1 HEY2 L1CAM LDB1 MYH9 NF1 NKX6-1 NRCAM NRP1 NRP2 OPHN1 PLG PML PTCH1 RASA1 RTN1 SCG2 SHH SLIT1 THY1 TLE1 TLE3 UNC5C VEGFA VLDLR
HALLMARK_HEME_METABOLISM > Genes involved in metabolism of heme (a cofactor consisting of iron and porphyrin) and erythroblast differentiation. ABCB6 ABCG2 ACP5 ACSL6 ADD1 ADD2 ADIPOR1 AGPAT4 AHSP ALAD ALAS2 ALDH1L1 ALDH6A1 ANK1 AQP3 ARHGEF12 ARL2BP ASNS ATG4A ATP6V0A1 BACH1 BCAM BLVRA BLVRB BMP2K BNIP3L BPGM BSG BTG2 BTRC C3 CA1 CA2 CAST CAT CCDC28A CCND3 CDC27 CDR2 CIR1 CLCN3 CLIC2 CPOX CROCCP2 CTNS CTSB CTSE DAAM1 DARC DCAF10 DCAF11 DCUN1D1 E2F2 EIF2AK1 ELL2 ENDOD1 EPB41 EPB42 EPB49 EPOR ERMAP EZH1 FAM46C FBXO34 FBXO7 FBXO9 FECH FN3K FOXJ2 FOXO3 FTCD GAPVD1 GATA1 GCLC GCLM GDE1 GLRX5 GMPS GYPA GYPB GYPC GYPE H1F0 HAGH HBB HBBP1 HBD HBQ1 HBZ HDGF HEBP1 HIST1H4C HMBS HTATIP2 HTRA2 ICAM4 IGSF3 ISCA1 JHDM1D KAT2B KEL KHNYN KLF1 KLF3 LAMP2 LMO2 LPIN2 LRP10 MAP2K3 MARCH2 MARCH8 MARK3 MBOAT2 MFHAS1 MGST3 MINPP1 MKRN1 MOCOS MOSPD1 MPP1 MXI1 MYL4 NARF NCOA4 NEK7 NFE2 NFE2L1 NNT NR3C1 NUDT4 OPTN OSBP2 P4HA2 PC PDZK1IP1 PGLS PICALM PIGQ PPOX PPP2R5B PQLC1 PRDX2 PSMD9 RAD23A RANBP10 RAP1GAP RBM38 RBM5 RCL1 RHAG RHCE RHD RIOK3 RNF123 RNF19A SDCBP SEC14L1 SELENBP1 SIDT2 SLC10A3 SLC11A2 SLC22A4 SLC25A37 SLC25A38 SLC2A1 SLC30A1 SLC30A10 SLC4A1 SLC6A8 SLC6A9 SLC7A11 SMOX SNCA SPTA1 SPTB SYNJ1 TAL1 TCEA1 TFDP2 TFRC TMCC2 TMEM9B TNRC6B TNS1 TOP1 TRAK2 TRIM10 TRIM58 TSPAN5 TSPO2 TYR UBAC1 UCP2 UROD UROS USP15 VEZF1 XK XPO7 YPEL5
HALLMARK_HYPOXIA > Genes up-regulated in response to low oxygen levels (hypoxia). ADM ADORA2B AK4 AKAP12 ALDOA ALDOB ALDOC AMPD3 ANGPTL4 ANKZF1 ANXA2 ATF3 ATP7A B3GALT6 B4GALNT2 BCAN BCL2 BGN BHLHE40 BNIP3L BRS3 BTG1 CA12 CASP6 CAV1 CCNG2 CCRN4L CDKN1A CDKN1B CDKN1C CHST2 CHST3 CITED2 COL5A1 CP CSRP2 CTGF CXCR4 CXCR7 CYR61 DCN DDIT3 DDIT4 DPYSL4 DTNA DUSP1 EDN2 EFNA1 EFNA3 EGFR ENO1 ENO2 ENO3 ERO1L ERRFI1 ETS1 EXT1 F3 FAM162A FBP1 FOS FOSL2 FOXO3 GAA GALK1 GAPDH GAPDHS GBE1 GCK GCNT2 GLRX GPC1 GPC3 GPC4 GPI GRHPR GYS1 HAS1 HDLBP HEXA HK1 HK2 HMOX1 HOXB9 HS3ST1 HSPA5 IDS IER3 IGFBP1 IGFBP3 IL6 ILVBL INHA IRS2 ISG20 JMJD6 JUN KDELR3 KDM3A KIF5A KLF6 KLF7 KLHL24 LALBA LARGE LDHA LDHC LOX LXN MAFF MAP3K1 MIF MT1E MT2A MXI1 MYH9 NAGK NCAN NDRG1 NDST1 NDST2 NEDD4L NFIL3 NR3C1 P4HA1 P4HA2 PAM PCK1 PDGFB PDK1 PDK3 PFKFB3 PFKL PFKP PGAM2 PGF PGK1 PGM1 PGM2 PHKG1 PIM1 PKLR PKP1 PLAC8 PLAUR PLIN2 PNRC1 PPARGC1A PPFIA4 PPP1R15A PPP1R3C PRDX5 PRKCA PRKCDBP PTRF PYGM RBPJ RORA RRAGD S100A4 SAP30 SCARB1 SDC2 SDC3 SDC4 SELENBP1 SERPINE1 SIAH2 SLC25A1 SLC2A1 SLC2A3 SLC2A5 SLC37A4 SLC6A6 SRPX STBD1 STC1 STC2 SULT2B1 TES TGFB3 TGFBI TGM2 TIPARP TKTL1 TMEM45A TNFAIP3 TPBG TPD52 TPI1 TPST2 UGP2 VEGFA VHL VLDLR WISP2 WSB1 XPNPEP1 ZFP36 ZNF292
HALLMARK_IL2_STAT5_SIGNALING > Genes up-regulated by STAT5 in response to IL2 stimulation. ABCB1 ADAM19 AGER AHCY AHNAK AHR AKAP2 ALCAM AMACR ANXA4 APLP1 ARL4A BATF BATF3 BCL2 BCL2L1 BHLHE40 BMP2 BMPR2 CA2 CAPG CAPN3 CASP3 CCDC164 CCND2 CCND3 CCNE1 CCR4 CD44 CD48 CD79B CD81 CD83 CD86 CDC42SE2 CDC6 CDCP1 CDKN1C CISH CKAP4 COCH COL6A1 CSF1 CSF2 CST7 CTLA4 CTSZ CXCL10 CYFIP1 DCPS DENND5A DHRS3 ECM1 EMP1 ENO3 ENPP1 EOMES ETV4 F2RL2 FAH FAM126B FGL2 FLT3LG FURIN GABARAPL1 GADD45B GALM GATA1 GBP4 GLIPR2 GPR65 GPR83 GPX4 GSTO1 GUCY1B3 HIPK2 HK2 HOPX HUWE1 ICOS IFITM3 IFNGR1 IGF1R IGF2R IKZF2 IKZF4 IL10 IL10RA IL13 IL18R1 IL1R2 IL1RL1 IL2RA IL2RB IL3RA IL4R IRF4 IRF6 IRF8 ITGA6 ITGAE ITGAV ITIH5 KLF6 LCLAT1 LIF LRIG1 LRRC8C LTB MAFF MAP3K8 MAP6 MAPKAPK2 METTL20 MUC1 MXD1 MYC MYO1C MYO1E N6AMT2 NCOA3 NCS1 NDRG1 NFIL3 NFKBIZ NOP2 NRP1 NT5E ODC1 P2RX4 P4HA1 PDCD2L PENK PHLDA1 PHTF2 PIM1 PLAGL1 PLEC PLIN2 PLSCR1 PNP POU2F1 PPAP2A PRAF2 PRKCH PRNP PTCH1 PTGER2 PTH1R PTRH2 PUS1 RABGAP1L RGS16 RHOB RHOH RNH1 RORA RRAGD S100A1 SCN9A SELL SELP SERPINB6 SERPINC1 SH3BGRL2 SHE SLC1A5 SLC29A2 SLC2A3 SLC39A8 SMPDL3A SNX14 SNX9 SOCS1 SOCS2 SPP1 SPRED2 SPRY4 ST3GAL4 SWAP70 SYNGR2 SYT11 TGM2 TIAM1 TLR7 TNFRSF18 TNFRSF1B TNFRSF21 TNFRSF4 TNFRSF8 TNFRSF9 TNFSF10 TNFSF11 TRAF1 TTC39B TWSG1 UCK2 UMPS WLS XBP1
HALLMARK_IL6_JAK_STAT3_SIGNALING > Genes up-regulated by IL6 [GeneID=3569] via STAT3 [GeneID=6774], e.g., during acute phase response. A2M ACVR1B ACVRL1 BAK1 CBL CCL7 CCR1 CD14 CD36 CD38 CD44 CD9 CNTFR CRLF2 CSF1 CSF2 CSF2RA CSF2RB CSF3R CXCL1 CXCL10 CXCL11 CXCL13 CXCL3 CXCL9 DNTT EBI3 FAS GRB2 HAX1 HMOX1 IFNAR1 IFNGR1 IFNGR2 IL10RB IL12RB1 IL13RA1 IL15RA IL17RA IL17RB IL18R1 IL1B IL1R1 IL1R2 IL2RA IL2RG IL3RA IL4R IL6 IL6ST IL7 IL9R INHBE IRF1 IRF9 ITGA4 ITGB3 JUN LEPR LTB LTBR MAP3K8 MYD88 OSMR PDGFC PF4 PIK3R5 PIM1 PLA2G2A PTPN1 PTPN11 PTPN2 REG1A SOCS1 SOCS3 STAM2 STAT1 STAT2 STAT3 TGFB1 TLR2 TNF TNFRSF12A TNFRSF1A TNFRSF1B TNFRSF21 TYK2
HALLMARK_INFLAMMATORY_RESPONSE > Genes defining inflammatory response. ABCA1 ABI1 ACVR1B ACVR2A ADM ADORA2B ADRM1 AHR APLNR AQP9 ATP2A2 ATP2B1 ATP2C1 AXL BDKRB1 BEST1 BST2 BTG2 C3AR1 C5AR1 CALCRL CCL17 CCL2 CCL20 CCL22 CCL24 CCL5 CCL7 CCR7 CCRL2 CD14 CD40 CD48 CD55 CD69 CD70 CD82 CDKN1A CHST2 CLEC5A CMKLR1 CSF1 CSF3 CSF3R CX3CL1 CXCL10 CXCL11 CXCL6 CXCL9 CXCR6 CYBB DCBLD2 EBI3 EDN1 EIF2AK2 EMP3 EMR1 EREG F3 FFAR2 FPR1 FZD5 GABBR1 GCH1 GNA15 GNAI3 GP1BA GPC3 GPR132 GPR183 HAS2 HBEGF HIF1A HPN HRH1 ICAM1 ICAM4 ICOSLG IFITM1 IFNAR1 IFNGR2 IL10 IL10RA IL12B IL15 IL15RA IL18 IL18R1 IL18RAP IL1A IL1B IL1R1 IL2RB IL4R IL6 IL7R IL8 INHBA IRAK2 IRF1 IRF7 ITGA5 ITGB3 ITGB8 KCNA3 KCNJ2 KCNMB2 KIF1B KLF6 LAMP3 LCK LCP2 LDLR LIF LPAR1 LTA LY6E LYN MARCO MEFV MEP1A MET MMP14 MSR1 MXD1 MYC NAMPT NDP NFKB1 NFKBIA NLRP3 NMI NMUR1 NOD2 NPFFR2 OLR1 OPRK1 OSM OSMR P2RX4 P2RX7 P2RY2 PCDH7 PDE4B PDPN PIK3R5 PLAUR PROK2 PSEN1 PTAFR PTGER2 PTGER4 PTGIR PTPRE PVR RAF1 RASGRP1 RELA RGS1 RGS16 RHOG RIPK2 RNF144B ROS1 RTP4 SCARF1 SCN1B SELE SELL SELS SEMA4D SERPINE1 SGMS2 SLAMF1 SLC11A2 SLC1A2 SLC28A2 SLC31A1 SLC31A2 SLC4A4 SLC7A1 SLC7A2 SPHK1 SRI STAB1 TACR1 TACR3 TAPBP TIMP1 TLR1 TLR2 TLR3 TNFAIP6 TNFRSF1B TNFRSF9 TNFSF10 TNFSF15 TNFSF9 TPBG VIP
HALLMARK_INTERFERON_ALPHA_RESPONSE > Genes up-regulated in response to alpha interferon proteins. ADAR B2M BATF2 BST2 C1S CASP1 CASP8 CCRL2 CD47 CD74 CMPK2 CNP CSF1 CXCL10 CXCL11 DDX60 DHX58 EIF2AK2 ELF1 EPSTI1 FAM125A FAM46A FTSJD2 GBP2 GBP4 GMPR HERC6 HLA-C IFI27 IFI30 IFI35 IFI44 IFI44L IFIH1 IFIT2 IFIT3 IFITM1 IFITM2 IFITM3 IL15 IL4R IL7 IRF1 IRF2 IRF7 IRF9 ISG15 ISG20 LAMP3 LAP3 LGALS3BP LPAR6 LY6E MOV10 MX1 NCOA7 NMI NUB1 OAS1 OASL OGFR PARP12 PARP14 PARP9 PLSCR1 PNPT1 PRIC285 PROCR PSMA3 PSMB8 PSMB9 PSME1 PSME2 RIPK2 RNF31 RSAD2 RTP4 SAMD9 SAMD9L SELL SLC25A28 SP110 STAT2 TAP1 TDRD7 TMEM140 TRAFD1 TRIM14 TRIM21 TRIM25 TRIM26 TRIM5 TXNIP UBA7 UBE2L6 USP18 WARS
HALLMARK_INTERFERON_GAMMA_RESPONSE > Genes up-regulated in response to IFNG [GeneID=3458]. ADAR APOL6 ARID5B ARL4A AUTS2 B2M BANK1 BATF2 BPGM BST2 BTG1 C1R C1S CASP1 CASP3 CASP4 CASP7 CASP8 CCL2 CCL5 CCL7 CD274 CD38 CD40 CD69 CD74 CD86 CDKN1A CFB CFH CIITA CMKLR1 CMPK2 CSF2RB CXCL10 CXCL11 CXCL9 DDX58 DDX60 DHX58 EIF2AK2 EIF4E3 EPSTI1 FAS FCGR1A FGL2 FPR1 FTSJD2 GBP4 GBP6 GCH1 GPR18 GZMA HERC6 HIF1A HLA-A HLA-B HLA-DMA HLA-DQA1 HLA-DRB1 HLA-G ICAM1 IDO1 IFI27 IFI30 IFI35 IFI44 IFI44L IFIH1 IFIT1 IFIT2 IFIT3 IFITM2 IFITM3 IFNAR2 IL10RA IL15 IL15RA IL18BP IL2RB IL4R IL6 IL7 IRF1 IRF2 IRF4 IRF5 IRF7 IRF8 IRF9 ISG15 ISG20 ISOC1 ITGB7 JAK2 KLRK1 LAP3 LATS2 LCP2 LGALS3BP LY6E LYSMD2 MARCH1 METTL7B MT2A MTHFD2 MVP MX1 MX2 MYD88 NAMPT NCOA3 NFKB1 NFKBIA NLRC5 NMI NOD1 NUP93 OAS2 OAS3 OASL OGFR P2RY14 PARP12 PARP14 PDE4B PELI1 PFKP PIM1 PLA2G4A PLSCR1 PML PNP PNPT1 PRIC285 PSMA2 PSMA3 PSMB10 PSMB2 PSMB8 PSMB9 PSME1 PSME2 PTGS2 PTPN1 PTPN2 PTPN6 RAPGEF6 RBCK1 RIPK1 RIPK2 RNF213 RNF31 RSAD2 RTP4 SAMD9L SAMHD1 SECTM1 SELP SERPING1 SLAMF7 SLC25A28 SOCS1 SOCS3 SOD2 SP110 SPPL2A SRI SSPN ST3GAL5 ST8SIA4 STAT1 STAT2 STAT3 STAT4 TAP1 TAPBP TDRD7 TNFAIP2 TNFAIP3 TNFAIP6 TNFSF10 TOR1B TRAFD1 TRIM14 TRIM21 TRIM25 TRIM26 TXNIP UBE2L6 UPP1 USP18 VAMP5 VAMP8 VCAM1 WARS XAF1 XCL1 ZBP1 ZNFX1
HALLMARK_KRAS_SIGNALING_DN > Genes down-regulated by KRAS activation. ABCB11 ABCG4 ACTC1 ADCK3 ADRA2C AKR1B10 ALOX12B AMBN ARHGDIG ARPP21 ASB7 ATP4A ATP6V1B1 BARD1 BMPR1B BRDT BTG2 C5 CACNA1F CACNG1 CALCB CALML5 CAMK1D CAPN9 CCDC106 CCDC132 CCNA1 CCR8 CD207 CD40LG CD80 CDH16 CDKAL1 CELSR2 CHRNG CHST2 CKM CLDN16 CLDN8 CLPS CLSTN3 CNTFR COL2A1 COPZ2 CPA2 CPB1 CPEB3 CYP11B2 CYP39A1 DCC DLK2 DTNB EDAR EDN1 EDN2 EFHD1 EGF ENTPD7 EPHA5 FAM164C FAM46C FGF16 FGF22 FGFR3 FGGY FSHB GAMT GDNF GP1BA GP2 GPR19 GPR3 GPRC5C GRID2 GTF3C5 H2AFY2 HNF1A HSD11B2 HTR1B HTR1D IDUA IFI44L IFNG IGFBP2 IL12B IL5 INSL5 IRS4 ITGB1BP2 ITIH3 KCND1 KCNE2 KCNMB1 KCNN1 KCNQ2 KLHDC8A KLK7 KLK8 KRT1 KRT13 KRT15 KRT4 KRT5 LFNG LGALS7 LYPD3 MAGIX MAST3 MEFV MFSD6 MLL2 MSH5 MTHFR MX1 MYH7 MYO15A MYOT NGB NOS1 NPHS1 NR4A2 NR6A1 NRIP2 NTF3 NUDT11 ODZ2 OXT P2RX6 P2RY4 PARK2 PAX3 PAX4 PCDHB1 PDCD1 PDE6B PDK2 PKP1 PLAG1 PNMT PPYR1 PRODH PROP1 PTGFR PTPRJ RGS11 RIBC2 RSAD2 RYR1 RYR2 SCGB1A1 SCN10A SEPP1 SERPINA10 SERPINB2 SGK1 SHOX2 SIDT1 SKIL SLC12A3 SLC16A7 SLC25A23 SLC29A3 SLC30A3 SLC38A3 SLC5A5 SLC6A14 SLC6A3 SMPX SNCB SNN SOX10 SPHK2 SPRR3 SPTBN2 SSTR4 STAG3 SYNPO TAS2R4 TCF7L1 TCL1A TEX15 TFAP2B TFCP2L1 TFF2 TG TGFB2 TGM1 THNSL2 THRB TLX1 TNNI3 TSHB UGT2B17 UPK3B VPREB1 WNT16 YBX2 YPEL1 ZBTB16 ZFP112
HALLMARK_KRAS_SIGNALING_UP > Genes up-regulated by KRAS activation. ABCB1 ACE ADAM17 ADAM8 ADAMDEC1 AKAP12 AKT2 ALDH1A2 ALDH1A3 AMMECR1 ANGPTL4 ANKH ANO1 ANXA10 APOD ARG1 ATG10 AVL9 BIRC3 BMP2 BPGM BTBD3 BTC C3AR1 CA2 CAB39L CBL CBR4 CBX8 CCL20 CCND2 CD37 CDADC1 CFB CFH CFHR2 CIDEA CLEC4A CMKLR1 CPE CROT CSF2 CSF2RA CTSS CXCL10 CXCR4 DCBLD2 DNMBP DOCK2 DUSP6 ELTD1 EMP1 ENG EPB41L3 EPHB2 EREG ERO1L ETS1 ETV1 ETV4 ETV5 EVI5 F13A1 F2RL1 FAM190B FBXO4 FCER1G FGF9 FLT4 FUCA1 G0S2 GABRA3 GADD45G GALNT3 GFPT2 GLRX GNG11 GPNMB GPR124 GPRC5B GUCY1A3 GYPC HBEGF HDAC9 HIST1H2BB HKDC1 HOXD11 HSD11B1 ID2 IGF2 IGFBP3 IKZF1 IL10RA IL1B IL1RL2 IL2RG IL33 IL7R INHBA IRF8 ITGA2 ITGB2 ITGBL1 JUP KCNN4 KIF5C KLF4 LAPTM5 LAT2 LCP1 LIF LY96 MAFB MALL MAP3K1 MAP4K1 MAP7 MMD MMP10 MMP11 MMP9 MPZL2 MTMR10 MYCN NAP1L2 NGF NIN NR0B2 NR1H4 NRP1 PCP4 PCSK1N PDCD1LG2 PECAM1 PEG3 PIGR PLAT PLAU PLAUR PLEK2 PLVAP PPBP PPP1R15A PRDM1 PRKG2 PRRX1 PSMB8 PTBP2 PTCD2 PTGS2 PTPRR RABGAP1L RBM4 RBP4 RELN RETN RGS16 SATB1 SCG3 SCG5 SCN1B SDCCAG8 SEMA3B SERPINA3 SLMO2 SLPI SNAP25 SNAP91 SOX9 SPARCL1 SPON1 SPP1 SPRY2 ST6GAL1 STRN TFPI TLR8 TMEM100 TMEM158 TMEM176A TMEM176B TNFAIP3 TNFRSF1B TNNT2 TOR1AIP2 TPH1 TRAF1 TRIB1 TRIB2 TSPAN1 TSPAN13 TSPAN7 USH1C USP12 VWA5A WDR33 WNT7A YRDC ZNF277 ZNF639
HALLMARK_MITOTIC_SPINDLE > Genes important for mitotic spindle assembly. ABI1 ABL1 ABR ACTN4 AKAP13 ALMS1 ALS2 ANLN APC ARAP3 ARF6 ARFGEF1 ARFIP2 ARHGAP10 ARHGAP27 ARHGAP29 ARHGAP4 ARHGAP5 ARHGDIA ARHGEF11 ARHGEF12 ARHGEF2 ARHGEF3 ARHGEF7 ARL8A ATG4B AURKA AZI1 BCAR1 BCL2L11 BCR BIN1 BIRC5 BRCA2 BUB1 CAPZB CCDC88A CCNB2 CD2AP CDC27 CDC42 CDC42BPA CDC42EP1 CDC42EP2 CDC42EP4 CDK1 CDK5RAP2 CENPE CENPF CENPJ CEP192 CEP250 CEP57 CEP72 CKAP5 CLASP1 CLIP1 CLIP2 CNTRL CNTROB CRIPAK CSNK1D CTTN CYTH2 DLG1 DLGAP5 DOCK2 DOCK4 DST DYNC1H1 DYNLL2 ECT2 EPB41 EPB41L2 ESPL1 EZR FARP1 FBXO5 FGD4 FGD6 FLNA FLNB FSCN1 GEMIN4 GSN HDAC6 HOOK3 INCENP ITSN1 KATNA1 KATNB1 KIF11 KIF15 KIF1B KIF20B KIF22 KIF23 KIF2C KIF3B KIF3C KIF4A KIF5B KIFAP3 KLC1 KNTC1 KPTN LATS1 LLGL1 LMNB1 LRPPRC MAP1S MAP3K11 MAPRE1 MARCKS MARK4 MID1 MID1IP1 MYH10 MYH9 MYO1E MYO9B NCK1 NCK2 NDC80 NEDD9 NEK2 NET1 NF1 NIN NOTCH2 NUMA1 NUSAP1 OPHN1 PAFAH1B1 PALLD PCGF5 PCM1 PCNT PDLIM5 PIF1 PKD2 PLEKHG2 PLK1 PPP4R2 PRC1 PREX1 PXN RAB3GAP1 RABGAP1 RACGAP1 RALBP1 RANBP9 RAPGEF5 RAPGEF6 RASA1 RASA2 RASAL2 RFC1 RHOF RHOT2 RICTOR ROCK1 SAC3D1 SASS6 SEPT9 SHROOM1 SHROOM2 SMC1A SMC3 SMC4 SORBS2 SOS1 SPTAN1 SPTBN1 SSH2 STAU1 STK38L SUN2 SYNPO TAOK2 TBCD TIAM1 TLK1 TOP2A TPX2 TRIO TSC1 TTK TUBA4A TUBD1 TUBGCP2 TUBGCP3 TUBGCP5 TUBGCP6 UXT VCL WASF1 WASF2 WASL YWHAE
HALLMARK_MTORC1_SIGNALING > Genes up-regulated through activation of mTORC1 complex. ABCF2 ACACA ACLY ACSL3 ACTR2 ACTR3 ADD3 ADIPOR2 AK4 ALDOA ARPC5L ASNS ATP2A2 ATP5G1 ATP6V1D AURKA BCAT1 BHLHE40 BTG2 BUB1 CACYBP CALR CANX CCNF CCNG1 CCT6A CD9 CDC25A CDKN1A CFP COPS5 CORO1A CTH CTSC CXCR4 CYB5B CYP51A1 DAPP1 DDIT3 DDIT4 DDX39A DHCR24 DHCR7 DHFR EBP EDEM1 EEF1E1 EGLN3 EIF2S2 ELOVL5 ELOVL6 ENO1 EPRS ERO1L ETF1 FADS1 FADS2 FAM129A FDXR FGL2 FKBP2 G6PD GAPDH GBE1 GCLC GGA2 GLA GLRX GMPS GOT1 GPI GSK3B GSR GTF2H1 HK2 HMBS HMGCR HMGCS1 HPRT1 HSP90B1 HSPA4 HSPA5 HSPA9 HSPD1 HSPE1 IDH1 IDI1 IFI30 IFRD1 IGFBP5 IMMT INSIG1 ITGB2 LDHA LDLR LGMN LTA4H M6PR MAP2K3 MCM2 MCM4 ME1 MLLT11 MTHFD2 MTHFD2L NAMPT NFIL3 NFKBIB NFYC NMT1 NUFIP1 NUP205 NUPR1 P4HA1 PDAP1 PDK1 PFKL PGK1 PGM1 PHGDH PIK3R3 PITPNB PLK1 PLOD2 PNO1 PNP POLR3G PPA1 PPIA PPP1R15A PRDX1 PSAT1 PSMA3 PSMA4 PSMB5 PSMC2 PSMC4 PSMC6 PSMD12 PSMD13 PSMD14 PSME3 PSMG1 PSPH QDPR RAB1A RDH11 RIT1 RPA1 RPN1 RRM2 RRP9 SC5DL SCD SDF2L1 SEC11A SERP1 SERPINH1 SHMT2 SKAP2 SLA SLC1A4 SLC1A5 SLC2A1 SLC2A3 SLC37A4 SLC6A6 SLC7A11 SLC7A5 SLC9A3R1 SORD SQLE SQSTM1 SRD5A1 SSR1 STARD4 STC1 STIP1 SYTL2 TBK1 TCEA1 TES TFRC TM7SF2 TMEM97 TOMM40 TPI1 TRIB3 TUBA4A TUBG1 TXNRD1 UBE2D3 UCHL5 UFM1 UNG USO1 VLDLR WARS XBP1 YKT6
HALLMARK_MYC_TARGETS_V1 > A subgroup of genes regulated by MYC - version 1 (v1). ABCE1 ACP1 AIMP2 AP3S1 APEX1 BUB3 C1QBP CAD CANX CBX3 CCNA2 CCT2 CCT3 CCT4 CCT5 CCT7 CDC20 CDC45 CDK2 CDK4 CLNS1A CNBP COPS5 COX5A CSTF2 CTPS CUL1 CYC1 DDX18 DDX21 DEK DHX15 DUT EEF1B2 EIF1AX EIF2S1 EIF2S2 EIF3B EIF3D EIF3J EIF4A1 EIF4E EIF4G2 EIF4H EPRS ERH ETF1 EXOSC7 FAM120A FBL G3BP1 GLO1 GNB2L1 GNL3 GOT2 GSPT1 H2AFZ HDAC2 HDDC2 HDGF HNRNPA1 HNRNPA2B1 HNRNPA3 HNRNPC HNRNPD HNRNPR HNRNPU HPRT1 HSP90AB1 HSPD1 HSPE1 IARS IFRD1 ILF2 IMPDH2 KARS KPNA2 KPNB1 LDHA LSM2 LSM7 MAD2L1 MCM2 MCM4 MCM5 MCM6 MCM7 MRPL23 MRPL9 MRPS18B MYC NAP1L1 NCBP1 NCBP2 NDUFAB1 NHP2 NME1 NOLC1 NOP16 NOP56 NPM1 ODC1 ORC2 PA2G4 PABPC1 PABPC4 PCBP1 PCNA PGK1 PHB PHB2 POLD2 POLE3 PPIA PPM1G PRDX3 PRDX4 PRPF31 PRPS2 PSMA1 PSMA2 PSMA4 PSMA6 PSMA7 PSMB2 PSMB3 PSMC4 PSMC6 PSMD1 PSMD14 PSMD3 PSMD7 PSMD8 PTGES3 PWP1 RAD23B RAN RANBP1 RFC4 RNPS1 RPL14 RPL18 RPL22 RPL34 RPL6 RPLP0 RPS10 RPS2 RPS3 RPS5 RPS6 RRM1 RRP9 RSL1D1 RUVBL2 SERBP1 SET SF3A1 SF3B3 SLC25A3 SMARCC1 SNRPA SNRPA1 SNRPB2 SNRPD1 SNRPD2 SNRPD3 SNRPG SRM SRPK1 SRSF1 SRSF2 SRSF3 SRSF7 SSB SSBP1 STARD7 SYNCRIP TARDBP TCP1 TFDP1 TOMM70A TRA2B TRIM28 TUFM TXNL4A TYMS U2AF1 UBA2 UBE2E1 UBE2L3 USP1 VBP1 VDAC1 VDAC3 XPO1 XPOT XRCC6 YWHAE YWHAQ
HALLMARK_MYC_TARGETS_V2 > A subgroup of genes regulated by MYC - version 2 (v2). AIMP2 BYSL CBX3 CDK4 DCTPP1 DDX18 DUSP2 EXOSC5 FARSA GNL3 GRWD1 HK2 HSPD1 HSPE1 IMP4 IPO4 LAS1L MAP3K6 MCM4 MCM5 MPHOSPH10 MRTO4 MYBBP1A MYC NDUFAF4 NIP7 NOC4L NOLC1 NOP16 NOP2 NOP56 NPM1 PA2G4 PES1 PHB PLK1 PLK4 PPAN PPRC1 PRMT3 PUS1 RABEPK RCL1 RRP12 RRP9 SLC19A1 SLC29A2 SORD SRM SUPV3L1 TBRG4 TCOF1 TFB2M TMEM97 UNG UTP20 WDR43 WDR74
HALLMARK_MYOGENESIS > Genes involved in development of skeletal muscle (myogenesis). ABLIM1 ACHE ACSL1 ACTA1 ACTC1 ACTN2 ACTN3 ADAM12 ADCY9 AEBP1 AGL AGRN AK1 AKT2 ANKRD2 APLNR APOD APP ATP2A1 ATP6AP1 BAG1 BDKRB2 BHLHE40 BIN1 CACNA1H CACNG1 CAMK2B CASQ1 CASQ2 CAV3 CD36 CDH13 CDKN1A CFD CHRNA1 CHRNB1 CHRNG CKB CKM CKMT2 CLU CNN3 COL15A1 COL1A1 COL3A1 COL4A2 COL6A2 COL6A3 COX6A2 COX7A1 CRAT CRYAB CSRP3 CTF1 DAPK2 DES DMD DMPK DTNA EFS EIF4A2 ENO3 EPHB3 ERBB3 FABP3 FDPS FGF2 FHL1 FKBP1B FLII FOXO4 FST FXYD1 GAA GABARAPL2 GADD45B GJA5 GNAO1 GPX3 GSN HBEGF HDAC5 HRC HSPB2 HSPB8 IFRD1 IGF1 IGFBP3 IGFBP7 ITGA7 ITGB1 ITGB4 ITGB5 KCNH1 KCNH2 KIFC3 KLF5 LAMA2 LARGE LDB3 LPIN1 LSP1 MAPK12 MAPRE3 MB MEF2A MEF2C MEF2D MRAS MYBPC3 MYBPH MYF6 MYH1 MYH11 MYH2 MYH3 MYH4 MYH7 MYH8 MYH9 MYL1 MYL2 MYL3 MYL4 MYL6B MYL7 MYLK MYLPF MYO1C MYOG MYOM1 MYOM2 MYOZ1 NAV2 NCAM1 NOS1 NOTCH1 NQO1 OCEL1 PC PDE4DIP PDLIM7 PFKM PGAM2 PICK1 PKIA PLXNB2 PPFIA4 PPP1R3C PRNP PSEN2 PTGIS PTP4A3 PVALB PYGM RB1 REEP1 RIT1 RYR1 SCD SCHIP1 SGCA SGCD SGCG SH2B1 SH3BGR SIRT2 SLC6A8 SLN SMTN SOD3 SORBS1 SORBS3 SPARC SPDEF SPEG SPHK1 SPTAN1 SSPN ST5 STC2 SVIL SYNGR2 TAGLN TCAP TEAD4 TGFB1 TNNC1 TNNC2 TNNI1 TNNI2 TNNT1 TNNT2 TNNT3 TPD52L1 TPM2 TPM3 TSC2 VIPR1 WWTR1
HALLMARK_NOTCH_SIGNALING > Genes up-regulated by activation of Notch signaling. APH1A ARRB1 CCND1 CUL1 DLL1 DTX1 DTX2 DTX4 FBXW11 FZD1 FZD5 FZD7 HES1 HEYL JAG1 KAT2A LFNG MAML2 NOTCH1 NOTCH2 NOTCH3 PPARD PRKCA PSEN2 PSENEN RBX1 SAP30 SKP1 ST3GAL6 TCF7L2 WNT2 WNT5A
HALLMARK_OXIDATIVE_PHOSPHORYLATION > Genes encoding proteins involved in oxidative phosphorylation. ABCB7 ACAA1 ACAA2 ACADM ACADSB ACADVL ACAT1 ACO2 AFG3L2 AIFM1 ALAS1 ALDH6A1 ATP1B1 ATP5A1 ATP5B ATP5C1 ATP5D ATP5E ATP5F1 ATP5G1 ATP5G2 ATP5G3 ATP5H ATP5I ATP5J ATP5J2 ATP5L ATP5O ATP6AP1 ATP6V0B ATP6V0C ATP6V0E1 ATP6V1C1 ATP6V1D ATP6V1E1 ATP6V1F ATP6V1G1 ATP6V1H BAX BCKDHA BDH2 BRP44L CASP7 COX10 COX11 COX15 COX17 COX4I1 COX5A COX5B COX6A1 COX6B1 COX6C COX7A2 COX7A2L COX7B COX7C COX8A CPT1A CS CYB5A CYB5R3 CYC1 CYCS DECR1 DLAT DLD DLST ECH1 ECHS1 ECI1 ETFA ETFB ETFDH FDX1 FH FXN GLUD1 GOT2 GPI GPX4 GRPEL1 HADHA HADHB HCCS HSD17B10 HSPA9 HTRA2 IDH1 IDH2 IDH3A IDH3B IDH3G IMMT ISCA1 ISCU LDHA LDHB LRPPRC MAOB MDH1 MDH2 MFN2 MGST3 MRPL11 MRPL15 MRPL34 MRPL35 MRPS11 MRPS12 MRPS15 MRPS22 MRPS30 MTRF1 MTRR MTX2 NDUFA1 NDUFA2 NDUFA3 NDUFA4 NDUFA5 NDUFA6 NDUFA7 NDUFA8 NDUFA9 NDUFAB1 NDUFB1 NDUFB2 NDUFB3 NDUFB4 NDUFB5 NDUFB6 NDUFB7 NDUFB8 NDUFC1 NDUFC2 NDUFS1 NDUFS2 NDUFS3 NDUFS4 NDUFS6 NDUFS7 NDUFS8 NDUFV1 NDUFV2 NNT NQO2 OAT OGDH OPA1 OXA1L PDHA1 PDHB PDHX PDK4 PDP1 PHB2 PHYH PMPCA POLR2F POR PRDX3 RETSAT RHOT1 RHOT2 SDHA SDHB SDHC SDHD SLC25A11 SLC25A12 SLC25A20 SLC25A3 SLC25A4 SLC25A5 SLC25A6 SUCLA2 SUCLG1 SUPV3L1 SURF1 TCIRG1 TIMM10 TIMM13 TIMM17A TIMM50 TIMM8B TIMM9 TOMM22 TOMM70A UQCR10 UQCR11 UQCRB UQCRC1 UQCRC2 UQCRFS1 UQCRH UQCRQ VDAC1 VDAC2 VDAC3
HALLMARK_P53_PATHWAY > Genes involved in p53 pathways and networks. ABAT ABCC5 ABHD4 ACVR1B ADA ADCK3 AEN AK1 ALOX15B ANKRA2 APAF1 APP ATF3 BAIAP2 BAK1 BAX BLCAP BMP2 BTG1 BTG2 CASP1 CCND2 CCND3 CCNG1 CCNK CCP110 CD81 CD82 CDH13 CDK5R1 CDKN1A CDKN2A CDKN2AIP CDKN2B CEBPA CGRRF1 CLCA2 CSRNP2 CTSD CTSF CYFIP2 DCXR DDB2 DDIT3 DDIT4 DEF6 DGKA DNTTIP2 DRAM1 EI24 EPHA2 EPHX1 EPS8L2 ERCC5 F2R FAM162A FAS FBXW7 FDXR FGF13 FOS FOXO3 FUCA1 GADD45A GLS2 GM2A GNB2L1 GPX2 H2AFJ HBEGF HDAC3 HEXIM1 HINT1 HIST1H1C HIST3H2A HMOX1 HRAS HSPA4L IER3 IER5 IFI30 IKBKAP IL1A INHBB IP6K2 IRAK1 ISCU ITGB4 JAG2 JUN KIF13B KLF4 KLK8 KRT17 LDHB LIF LRMP MAPKAPK3 MDM2 MKNK2 MXD1 MXD4 NDRG1 NHLH2 NINJ1 NOL8 NOTCH1 NUDT15 NUPR1 OSGIN1 PCNA PDGFA PERP PHLDA3 PIDD PITPNC1 PLK2 PLK3 PLXNB2 PMM1 POLH POM121 PPM1D PPP1R15A PRKAB1 PRMT2 PROCR PTPN14 PTPRE PVT1 RAB40C RAD51C RAD9A RALGDS RAP2B RB1 RCHY1 RETSAT RGS16 RHBDF2 RNF19B RPL18 RPL36 RPS12 RPS27L RRAD RRP8 RXRA S100A10 S100A4 SAT1 SDC1 SEC61A1 SERPINB5 SERTAD3 SESN1 SFN SLC19A2 SLC35D1 SLC3A2 SLC7A11 SOCS1 SP1 SPHK1 ST14 STEAP3 STOM TAP1 TAX1BP3 TCHH TCN2 TGFA TGFB1 TM4SF1 TM7SF3 TNFSF9 TNNI1 TOB1 TP53 TP63 TPD52L1 TPRKB TRAF4 TRAFD1 TRIAP1 TRIB3 TSC22D1 TSPYL2 TXNIP UPP1 VAMP8 VDR VWA5A WRAP73 WWP1 XPC ZBTB16 ZFP36L1 ZMAT3 ZNF365
HALLMARK_PANCREAS_BETA_CELLS > Genes specifically up-regulated in pancreatic beta cells. ABCC8 AKT3 CHGA DCX DPP4 ELP4 FOXA2 FOXO1 G6PC2 GCG GCK HNF1A IAPP INS INSM1 ISL1 LMO2 MAFB NEUROD1 NEUROG3 NKX2-2 NKX6-1 PAK3 PAX4 PAX6 PCSK1 PCSK2 PDX1 PKLR SCGN SEC11A SLC2A2 SPCS1 SRP14 SRP9 SRPRB SST STXBP1 SYT13 VDR
HALLMARK_PEROXISOME > Genes encoding components of peroxisome. ABCB1 ABCB4 ABCB9 ABCC5 ABCC8 ABCD1 ABCD2 ABCD3 ACAA1 ACOT8 ACOX1 ACSL1 ACSL4 ACSL5 ALB ALDH1A1 ALDH9A1 ATXN1 BCL10 CACNA1B CADM1 CAT CDK7 CEL CLN6 CLN8 CNBP CRABP1 CRABP2 CRAT CTBP1 CTPS DHCR24 DHRS3 DIO1 DLG4 ECH1 ECI2 EHHADH ELOVL5 EPHX2 ERCC1 ERCC3 ESR2 FABP6 FADS1 FDPS FIS1 GNPAT GSTK1 HAO2 HMGCL HRAS HSD11B2 HSD17B11 HSD17B4 HSD3B7 IDE IDH1 IDH2 IDI1 ISOC1 ITGB1BP1 LONP2 MLYCD MSH2 MVP NR1I2 NUDT19 PABPC1 PEX11A PEX11B PEX13 PEX14 PEX2 PEX5 PEX6 PRDX1 PRDX5 RDH11 RETSAT RXRG SCGB1A1 SCP2 SEMA3C SERPINA6 SIAH1 SLC23A2 SLC25A17 SLC25A19 SLC25A4 SLC27A2 SLC35B2 SMARCC1 SOD1 SOD2 STS SULT2B1 TOP2A TSPO TTR UGT2B17 VPS4B YWHAH
HALLMARK_PI3K_AKT_MTOR_SIGNALING > Genes up-regulated by activation of the PI3K/AKT/mTOR pathway. ACACA ACTR2 ACTR3 ADCY2 ADRBK1 AKT1 AKT1S1 AP2M1 ARF1 ARHGDIA ARPC3 ATF1 CAB39 CAB39L CALR CAMK4 CDK1 CDK2 CDK4 CDKN1A CDKN1B CFL1 CLTC CSNK2B CXCR4 DAPP1 DDIT3 DUSP3 E2F1 ECSIT EGFR EIF4E FASLG FGF17 FGF22 FGF6 GNA14 GNGT1 GRB2 GSK3B HRAS HSP90B1 IL2RG IL4 IRAK4 ITPR2 LCK MAP2K3 MAP2K6 MAP3K7 MAPK1 MAPK10 MAPK8 MAPK9 MAPKAP1 MKNK1 MKNK2 MYD88 NCK1 NFKBIB NGF NOD1 PAK4 PDK1 PFN1 PIK3R3 PIKFYVE PIN1 PITX2 PLA2G12A PLCB1 PLCG1 PPP1CA PPP2R1B PRKAA2 PRKAG1 PRKAR2A PRKCB PTEN PTPN11 RAC1 RAF1 RALB RIPK1 RIT1 RPS6KA1 RPS6KA3 RPTOR SFN SLA SLC2A1 SMAD2 SQSTM1 STAT2 TBK1 THEM4 TIAM1 TNFRSF1A TRAF2 TRIB3 TSC2 UBE2D3 UBE2N VAV3 YWHAB
HALLMARK_PROTEIN_SECRETION > Genes involved in protein secretion pathway. ABCA1 ADAM10 ANP32E AP1G1 AP2B1 AP2M1 AP2S1 AP3B1 AP3S1 ARCN1 ARF1 ARFGAP3 ARFGEF1 ARFGEF2 ARFIP1 ATP1A1 ATP6V1B1 ATP6V1H ATP7A BET1 BNIP3 CAV2 CD63 CLCN3 CLN5 CLTA CLTC COG2 COPB1 COPB2 COPE CTSC DNM1L DOPEY1 DST EGFR ERGIC3 GALC GBF1 GLA GNAS GOLGA4 GOSR2 ICA1 IGF2R KIF1B KRT18 LAMP2 LMAN1 M6PR MAPK1 MON2 NAPA NAPG OCRL PAM PPT1 RAB14 RAB22A RAB2A RAB5A RAB9A RER1 RPS6KA3 SCAMP1 SCAMP3 SCRN1 SEC22B SEC24D SEC31A SGMS1 SH3GL2 SNAP23 SNX2 SOD1 SSPN STAM STX12 STX16 STX7 TMED10 TMED2 TMX1 TOM1L1 TPD52 TSG101 TSPAN8 USO1 VAMP3 VAMP4 VAMP7 VPS45 VPS4B YIPF6 YKT6 ZW10
HALLMARK_REACTIVE_OXIGEN_SPECIES_PATHWAY > Genes up-regulated by reactive oxigen species (ROS). ABCC1 ATOX1 CAT CDKN2D EGLN2 ERCC2 FES FTL G6PD GCLC GCLM GLRX GLRX2 GPX3 GPX4 GSR HBXIP HHEX HMOX2 IPCEF1 JUNB LSP1 MBP MGST1 MPO MSRA NDUFA6 NDUFB4 NDUFS2 NQO1 OXSR1 PDLIM1 PFKP PPP2R4 PRDX1 PRDX2 PRDX4 PRDX6 PRNP SBNO2 SCAF4 SELS SOD1 SOD2 SRXN1 STK25 TXN TXNRD1 TXNRD2
HALLMARK_SPERMATOGENESIS > Genes up-regulated during production of male gametes (sperm), as in spermatogenesis. ACE ACRBP ACRV1 ACTL7B ADAD1 ADAM2 ADCYAP1 AGFG1 AKAP4 ALOX15 ARL4A ART3 AURKA BRAF BUB1 CAMK4 CCNA1 CCNB2 CCT6B CDK1 CDKN3 CFTR CHFR CHRM4 CLGN CLPB CLVS1 CNIH2 COIL CRISP2 CSNK2A2 CST8 DBF4 DCC DDX25 DDX4 DMC1 DMRT1 DNAJB8 DPEP3 ELOVL3 EZH2 FAM164C GAD1 GAPDHS GFI1 GMCL1 GPR182 GRM8 GSG1 GSTM3 HBZ HIST1H1T HOXB1 HSPA1L HSPA2 HSPA4L HTR5A IDE IFT88 IL12RB2 IL13RA2 IP6K1 JAM3 KIF2C LDHC LPIN1 MAP7 MAST2 MEP1B MLF1 MLLT10 MTNR1A MTOR NAA11 NCAPH NEFH NEK2 NF2 NOS1 NPHP1 NPY5R OAZ3 ODF1 PACRG PAPOLB PARP2 PCSK1N PCSK4 PDHA2 PEBP1 PGK2 PGS1 PHF7 PHKG2 PIAS2 POMC PRKAR2A PRM2 PSMG1 RAD17 RFC4 RPL39L SCG3 SCG5 SEPT4 SHE SIRT1 SLC12A2 SLC2A5 SNAP91 SPATA6 STAM2 STRBP SYCP1 TALDO1 TCP11 TEKT2 THEG TKTL1 TLE4 TNNI3 TNP1 TNP2 TOPBP1 TSN TSSK2 TTK TUBA3C TULP2 VDAC3 YBX2 ZC3H14 ZNRF4 ZPBP
HALLMARK_TGF_BETA_SIGNALING > Genes up-regulated in response to TGFB1 [GeneID=7040]. ACVR1 APC ARID4B BCAR3 BMP2 BMPR1A BMPR2 CDH1 CDK9 CDKN1C CTNNB1 ENG FKBP1A FNTA FURIN HDAC1 HIPK2 ID1 ID2 ID3 IFNGR2 JUNB KLF10 LEFTY2 LTBP2 MAP3K7 NCOR2 NOG PMEPA1 PPM1A PPP1CA PPP1R15A RAB31 RHOA SERPINE1 SKI SKIL SLC20A1 SMAD1 SMAD3 SMAD6 SMAD7 SMURF1 SMURF2 SPTBN1 TGFB1 TGFBR1 TGIF1 THBS1 TJP1 TRIM33 UBE2D3 WWTR1 XIAP
HALLMARK_TNFA_SIGNALING_VIA_NFKB > Genes regulated by NF-kB in response to TNF [GeneID=7124]. ABCA1 AREG ATF3 ATP2B1 B4GALT1 B4GALT5 BCL2A1 BCL3 BCL6 BHLHE40 BIRC2 BIRC3 BMP2 BTG1 BTG2 BTG3 CCL2 CCL20 CCL4 CCL5 CCND1 CCNL1 CCRL2 CD44 CD69 CD80 CD83 CDKN1A CEBPB CEBPD CFLAR CLCF1 CSF1 CSF2 CXCL1 CXCL10 CXCL11 CXCL2 CXCL3 CXCL6 CXCR7 CYR61 DDX58 DENND5A DNAJB4 DRAM1 DUSP1 DUSP2 DUSP4 DUSP5 EDN1 EFNA1 EGR1 EGR2 EGR3 EHD1 EIF1 ETS2 F2RL1 F3 FJX1 FOS FOSB FOSL1 FOSL2 FUT4 G0S2 GADD45A GADD45B GCH1 GEM GFPT2 GPR183 HBEGF HES1 ICAM1 ICOSLG ID2 IER2 IER3 IER5 IFIH1 IFIT2 IFNGR2 IL12B IL15RA IL18 IL1A IL1B IL23A IL6 IL6ST IL7R INHBA IRF1 IRS2 JAG1 JUN JUNB KDM6B KLF10 KLF2 KLF4 KLF6 KLF9 KYNU LAMB3 LDLR LIF LITAF MAFF MAP2K3 MAP3K8 MARCKS MCL1 MSC MXD1 MYC NAMPT NFAT5 NFE2L2 NFIL3 NFKB1 NFKB2 NFKBIA NFKBIE NINJ1 NR4A1 NR4A2 NR4A3 OLR1 PANX1 PDE4B PDLIM5 PER1 PFKFB3 PHLDA1 PHLDA2 PLAU PLAUR PLEK PLK2 PMEPA1 PNRC1 PPAP2B PPP1R15A PTGER4 PTGS2 PTPRE PTX3 RCAN1 REL RELA RELB RHOB RIPK2 RNF19B SAT1 SDC4 SERPINB2 SERPINB8 SERPINE1 SGK1 SIK1 SLC16A6 SLC2A3 SLC2A6 SMAD3 SNN SOCS3 SOD2 SPHK1 SPSB1 SQSTM1 STAT5A TANK TAP1 TGIF1 TIPARP TLR2 TNC TNF TNFAIP2 TNFAIP3 TNFAIP6 TNFAIP8 TNFRSF9 TNFSF9 TNIP1 TNIP2 TRAF1 TRIB1 TRIP10 TSC22D1 TUBB2A VEGFA YRDC ZBTB10 ZC3H12A ZFP36
HALLMARK_UNFOLDED_PROTEIN_RESPONSE > Genes up-regulated during unfolded protein response, a cellular stress response related to the endoplasmic reticulum. ALDH18A1 ARFGAP1 ASNS ATF3 ATF4 ATF6 ATP6V0D1 BAG3 BANF1 CALR CCL2 CEBPB CEBPG CHAC1 CKS1B CNOT2 CNOT4 CNOT6 CXXC1 DCP1A DCP2 DCTN1 DDIT4 DDX10 DKC1 DNAJA4 DNAJB9 DNAJC3 EDC4 EDEM1 EEF2 EIF2AK3 EIF2S1 EIF4A1 EIF4A2 EIF4A3 EIF4E EIF4EBP1 EIF4G1 ERN1 ERO1L EXOC2 EXOSC1 EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC9 FKBP14 FUS GEMIN4 GOSR2 H2AFX HERPUD1 HSP90B1 HSPA5 HSPA9 HYOU1 IARS IFIT1 IGFBP1 IMP3 KDELR3 KHSRP KIF5B LSM1 LSM4 MTHFD2 NFYA NFYB NHP2 NOLC1 NOP14 NOP56 NPM1 OBFC2A PAIP1 PARN PDIA5 PDIA6 POP4 PREB PSAT1 RPS14 RRP9 SDAD1 SEC11A SEC31A SERP1 SHC1 SKIV2L2 SLC1A4 SLC30A5 SLC7A5 SPCS1 SPCS3 SRPR SRPRB SSR1 STC2 TARS TATDN2 TSPYL2 TTC37 TUBB2A VEGFA WFS1 WIPI1 XBP1 XPOT YIF1A YWHAZ ZBTB17
HALLMARK_UV_RESPONSE_DN > Genes down-regulated in response to ultraviolet (UV) radiation. ABCC1 ACVR2A ADD3 ADORA2B AGGF1 AKT3 AMPH ANXA2 ANXA4 APBB2 ARHGEF9 ATP2B1 ATP2B4 ATP2C1 ATP5S ATRN ATRX ATXN1 BCKDHB BDNF BHLHE40 BMPR1A CACNA1A CAP2 CAV1 CDC42BPA CDK13 CDKN1B CDON CELF2 CITED2 COL11A1 COL1A1 COL1A2 COL3A1 COL5A2 CYR61 DAB2 DBP DDAH1 DLC1 DLG1 DUSP1 DYRK1A EFEMP1 ERBB2 F3 FAM179B FBLN5 FHL2 FYN FZD2 GCNT1 GJA1 GRK5 HAS2 ICA1 ID1 IGF1R IGFBP5 INPP4B INSIG1 IRS1 ITGB3 KALRN KCNMA1 KIT LAMC1 LDLR LPAR1 LPHN2 LTBP1 MAGI2 MAP1B MAP2K5 MAPK14 MET MGLL MGMT MIOS MMP16 MRPS31 MT1E MTA1 MYC NEK7 NFIB NFKB1 NIPBL NOTCH2 NR1D2 NR3C1 NRP1 PAPD7 PDGFRB PDLIM5 PEX14 PHF3 PIAS3 PIK3CD PIK3R3 PLCB4 PMP22 PPAP2B PPARG PRDM2 PRKAR2B PRKCA PRKCE PTEN PTGFR PTPN21 PTPRM RASA2 RBPMS RGS4 RND3 RUNX1 RXRA SCAF8 SCHIP1 SCN8A SDC2 SERPINE1 SFMBT1 SIPA1L1 SLC22A18 SLC7A1 SMAD3 SMAD7 SNAI2 SPOP SRI SYNE1 SYNJ2 TFPI TGFBR2 TGFBR3 TJP1 VAV2 VLDLR WDR37 YTHDC1 ZMIZ1
HALLMARK_UV_RESPONSE_UP > Genes up-regulated in response to ultraviolet (UV) radiation. ABCB1 ACAA1 ALAS1 ALDOA AMD1 AP2S1 APOM AQP3 ARRB2 ASNS ATF3 ATP6V1C1 ATP6V1F BAK1 BCL2L11 BID BMP2 BSG BTG1 BTG2 BTG3 C4BPB CA2 CASP3 CCK CCND3 CCNE1 CDC34 CDC5L CDK2 CDKN1C CDKN2B CDO1 CEBPG CHKA CHRNA5 CLCN2 CLTB CNP COL2A1 CREG1 CTSL2 CXCL2 CYB5B CYB5R1 CYP1A1 DDX21 DGAT1 DLG4 DNAJA1 DNAJB1 E2F5 EIF2C2 EIF2S3 EIF5 ENO2 EPCAM EPHX1 FEN1 FGF18 FKBP4 FMO1 FOS FOSB FURIN GAL GCH1 GGH GLS GPX3 GRINA GRPEL1 H2AFX HLA-F HMOX1 HNRNPU HSPA13 HSPA2 HTR7 HYAL2 ICAM1 IGFBP2 IL6 IL6ST IRF1 JUNB KCNH2 KLHDC3 LHX2 LYN MAOA MAPK8IP2 MARK2 MGAT1 MMP14 MRPL23 MSX1 NAT1 NFKBIA NKX2-5 NPTX2 NPTXR NR4A1 NTRK3 NUPL1 NXF1 OLFM1 ONECUT1 PARP2 PDAP1 PDLIM3 PLCL1 POLE3 POLG2 POLR2H PPAT PPIF PPP1R2 PPT1 PRKACA PRKCD PRPF3 PSMC3 PTPRD RAB27A RASGRP1 RET RFC4 RHOB RPN1 RRAD RXRB SEPW1 SHOX2 SIGMAR1 SLC25A4 SLC6A12 SLC6A8 SOD2 SPR SQSTM1 STARD3 STIP1 STK25 SULT1A1 TACR3 TAP1 TARS TCHH TFRC TGFBRAP1 TMBIM6 TST TUBA4A TYRO3 UROD WIZ YKT6
HALLMARK_WNT_BETA_CATENIN_SIGNALING > Genes up-regulated by activation of WNT signaling through accumulation of beta catenin CTNNB1 [GeneID=1499]. ADAM17 AXIN1 AXIN2 CCND2 CSNK1E CTNNB1 CUL1 DKK1 DKK4 DLL1 DVL2 FRAT1 FZD1 FZD8 GNAI1 HDAC11 HDAC2 HDAC5 HEY1 HEY2 JAG1 JAG2 KAT2A LEF1 MAML1 MYC NCOR2 NCSTN NKD1 NOTCH1 NOTCH4 NUMB PPARD PSEN2 PTCH1 RBPJ SKP2 TCF7 TP53 WNT1 WNT5B WNT6
HALLMARK_XENOBIOTIC_METABOLISM > Genes encoding proteins involved in processing of drugs and other xenobiotics. ABCC2 ABCC3 ABCD2 ABHD6 ACO2 ACOX1 ACOX2 ACOX3 ACP1 ACP2 ACSM1 ADH1C ADH5 ADH7 AHCY AKR1C2 AKR1C3 ALAS1 ALDH2 ALDH3A1 ALDH9A1 ANGPTL3 AOX1 AP4B1 APOE AQP9 ARG1 ARG2 ARPP19 ASL ATOH8 ATP2A2 BCAR1 BCAT1 BLVRB BPHL CA2 CASP6 CAT CBR1 CCL25 CD36 CDA CDO1 CES1 CFB CNDP2 COMT CROT CRP CSAD CYB5A CYFIP2 CYP17A1 CYP1A1 CYP1A2 CYP26A1 CYP27A1 CYP2C18 CYP2E1 CYP2J2 CYP2S1 CYP4F2 DAK DCXR DDAH2 DDC DDT DHPS DHRS1 DHRS7 ECH1 ELOVL5 ENPEP ENTPD5 EPHA2 EPHX1 ESR1 ETFDH ETS2 F10 F11 FABP1 FAH FAS FBLN1 FBP1 FETUB FMO1 FMO3 G6PC GABARAPL1 GAD1 GART GCH1 GCKR GCLC GCNT2 GNMT GSR GSS GSTA3 GSTM4 GSTO1 GSTT2 HACL1 HES6 HGFAC HMOX1 HNF4A HPRT1 HRG HSD11B1 HSD17B2 ID2 IDH1 IGF1 IGFBP1 IGFBP4 IL1R1 IRF8 ITIH1 ITIH4 JUP KARS KYNU LCAT LEAP2 LONP1 LPIN2 MAN1A1 MAOA MARCH6 MBL2 MCCC2 MPP2 MT2A MTHFD1 NDRG2 NFS1 NINJ1 NMT1 NPC1 NQO1 PAPSS2 PC PDK4 PDLIM5 PEMT PGD PGRMC1 PINK1 PLG PMM1 POR PPARD PROS1 PSMB10 PTGDS PTGES PTGES3 PTGR1 PTS PYCR1 RAP1GAP RBP4 REG1A RETSAT SAR1B SERPINA6 SERPINE1 SERTAD1 SHMT2 SLC12A4 SLC1A5 SLC22A1 SLC35B1 SLC35D1 SLC46A3 SLC6A12 SLC6A6 SMOX SPINT2 SSR3 TAT TDO2 TGFB2 TMBIM6 TMEM176B TMEM97 TNFRSF1A TPST1 TTPA TYR UGDH UPB1 UPP1 VNN1 VTN XDH