diff --git a/src/comment.rs b/src/comment.rs
index 4d565afc1e0..ca52d831f23 100644
--- a/src/comment.rs
+++ b/src/comment.rs
@@ -804,7 +804,8 @@ impl<'a> CommentRewrite<'a> {
         let should_wrap_comment = self.fmt.config.wrap_comments()
             && !is_markdown_header_doc_comment
             && unicode_str_width(line) > self.fmt.shape.width
-            && !has_url(line);
+            && !has_url(line)
+            && !is_table_item(line);
 
         if should_wrap_comment {
             match rewrite_string(line, &self.fmt, self.max_width) {
@@ -939,6 +940,18 @@ fn has_url(s: &str) -> bool {
         || REFERENCE_LINK_URL.is_match(s)
 }
 
+/// Returns true if the given string may be part of a Markdown table.
+fn is_table_item(mut s: &str) -> bool {
+    // This function may return false positive, but should get its job done in most cases (i.e.
+    // markdown tables with two column delimiters).
+    s = s.trim_start();
+    return s.starts_with('|')
+        && match s.rfind('|') {
+            Some(0) | None => false,
+            _ => true,
+        };
+}
+
 /// Given the span, rewrite the missing comment inside it if available.
 /// Note that the given span must only include comments (or leading/trailing whitespaces).
 pub(crate) fn rewrite_missing_comment(
diff --git a/tests/target/issue-4210-disabled.rs b/tests/target/issue-4210-disabled.rs
new file mode 100644
index 00000000000..3ba87aab8c5
--- /dev/null
+++ b/tests/target/issue-4210-disabled.rs
@@ -0,0 +1,15 @@
+// rustfmt-wrap_comments: false
+
+/// Table that is > 80 symbols:
+///
+/// | table | xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx |
+/// |-------|-----------------------------------------------------------------------------|
+/// | val   | x                                                                           |
+pub struct Item;
+
+/// Table value that is > 80 symbols:
+///
+/// | table    | heading
+/// |----------|-----------------------------------------------------------------------------
+/// | long val | Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua.
+pub struct Item2;
diff --git a/tests/target/issue-4210.rs b/tests/target/issue-4210.rs
new file mode 100644
index 00000000000..3fd96639082
--- /dev/null
+++ b/tests/target/issue-4210.rs
@@ -0,0 +1,15 @@
+// rustfmt-wrap_comments: true
+
+/// Table that is > 80 symbols:
+///
+/// | table | xxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxxx |
+/// |-------|-----------------------------------------------------------------------------|
+/// | val   | x                                                                           |
+pub struct Item;
+
+/// Table value that is > 80 symbols:
+///
+/// | table    | heading
+/// |----------|-----------------------------------------------------------------------------
+/// | long val | Lorem ipsum dolor sit amet, consectetur adipiscing elit, sed do eiusmod tempor incididunt ut labore et dolore magna aliqua.
+pub struct Item2;