diff --git a/src/Uno.UI/UI/Xaml/Controls/ListViewBase/ListViewBase.cs b/src/Uno.UI/UI/Xaml/Controls/ListViewBase/ListViewBase.cs
index fc7fae768e3e..7562036ef426 100644
--- a/src/Uno.UI/UI/Xaml/Controls/ListViewBase/ListViewBase.cs
+++ b/src/Uno.UI/UI/Xaml/Controls/ListViewBase/ListViewBase.cs
@@ -459,7 +459,7 @@ partial void OnSelectionModeChangedPartial(ListViewSelectionMode oldSelectionMod
 
 
 
-		internal override void OnItemClicked(int clickedIndex)
+		internal override void OnItemClicked(int clickedIndex, VirtualKeyModifiers modifiers)
 		{
 			// Note: don't call base.OnItemClicked(), because we override the default single-selection-only handling
 
@@ -487,7 +487,16 @@ internal override void OnItemClicked(int clickedIndex)
 						// The CollectionView may have intercepted the change
 						clickedIndex = collectionView.CurrentPosition;
 					}
-					SelectedIndex = clickedIndex;
+
+					if ((modifiers & VirtualKeyModifiers.Control) != 0 && clickedIndex == SelectedIndex)
+					{
+						SelectedIndex = -1;
+					}
+					else
+					{
+						SelectedIndex = clickedIndex;
+					}
+
 					break;
 				case ListViewSelectionMode.Multiple:
 				case ListViewSelectionMode.Extended:
diff --git a/src/Uno.UI/UI/Xaml/Controls/Primitives/Selector.cs b/src/Uno.UI/UI/Xaml/Controls/Primitives/Selector.cs
index 5360c1db799f..e57511fab0ff 100644
--- a/src/Uno.UI/UI/Xaml/Controls/Primitives/Selector.cs
+++ b/src/Uno.UI/UI/Xaml/Controls/Primitives/Selector.cs
@@ -13,6 +13,7 @@
 using Windows.UI.Xaml.Data;
 using Uno.UI.DataBinding;
 using Windows.Foundation.Collections;
+using Windows.System;
 using Uno.UI.Xaml.Controls;
 using Windows.UI.Xaml.Input;
 
@@ -555,9 +556,11 @@ internal override void OnItemsSourceGroupsChanged(object sender, NotifyCollectio
 			}
 		}
 
-		internal void OnItemClicked(SelectorItem selectorItem) => OnItemClicked(IndexFromContainer(selectorItem));
+		internal void OnItemClicked(SelectorItem selectorItem, VirtualKeyModifiers modifiers) => OnItemClicked(IndexFromContainer(selectorItem), modifiers);
 
-		internal virtual void OnItemClicked(int clickedIndex)
+		internal virtual void OnItemClicked(int clickedIndex) => OnItemClicked(clickedIndex, VirtualKeyModifiers.None);
+
+		internal virtual void OnItemClicked(int clickedIndex, VirtualKeyModifiers modifiers)
 		{
 			if (ItemsSource is ICollectionView collectionView)
 			{
diff --git a/src/Uno.UI/UI/Xaml/Controls/Primitives/SelectorItem.cs b/src/Uno.UI/UI/Xaml/Controls/Primitives/SelectorItem.cs
index dd389c01cfe8..5c3f94ef811d 100644
--- a/src/Uno.UI/UI/Xaml/Controls/Primitives/SelectorItem.cs
+++ b/src/Uno.UI/UI/Xaml/Controls/Primitives/SelectorItem.cs
@@ -342,7 +342,7 @@ protected override void OnPointerReleased(PointerRoutedEventArgs args)
 				_canRaiseClickOnPointerRelease = false;
 
 				update = ManipulationUpdateKind.Clicked;
-				Selector?.OnItemClicked(this);
+				Selector?.OnItemClicked(this, args.KeyModifiers);
 
 				// This should be automatically done by the pointers due to release, but if for any reason
 				// the state is invalid, this makes sure to not keep invalid capture longer than needed.