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Add better links #647

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9 changes: 5 additions & 4 deletions docs/src/examples/09_loopless.jl
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# Here we will use [`flux_balance_analysis`](@ref) and
# [`flux_variability_analysis`](@ref) to analyze a toy model of *E. coli* that
# is constrained in a way that removes all thermodynamically infeasible loops in the flux solution.
# For more details about the algorithm, see Schellenberger, Lewis, and, Palsson. "Elimination
# of thermodynamically infeasible loops in steady-state metabolic models.", *Biophysical
# journal*, 2011 (https://doi.org/10.1016/j.bpj.2010.12.3707).
# is constrained in a way that removes all thermodynamically infeasible loops in
# the flux solution. For more details about the algorithm, see [Schellenberger,
# and, Palsson., "Elimination of thermodynamically infeasible loops in
# steady-state metabolic models.", Biophysical Journal,
# 2011](https://doi.org/10.1016/j.bpj.2010.12.3707).

# If it is not already present, download the model:

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9 changes: 4 additions & 5 deletions docs/src/examples/10_crowding.jl
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# the toy *E. coli* model that additionally respects common protein crowding
# constraints. In particular, the model is limited by the amount of protein
# required to run certain reactions. If that data is available, the predictions
# are accordingly more realistic. See Beg, Qasim K., et al. "Intracellular
# crowding defines the mode and sequence of substrate uptake by Escherichia coli
# and constrains its metabolic activity." *Proceedings of the National Academy
# of Sciences*, 104.31, 2007, (https://doi.org/10.1073/pnas.0609845104) for more
# details.
# are accordingly more realistic. See [Beg, et al., "Intracellular crowding
# defines the mode and sequence of substrate uptake by Escherichia coli and
# constrains its metabolic activity.", Proceedings of the National Academy of
# Sciences,2007](https://doi.org/10.1073/pnas.0609845104) for more details.
#
# As usual, the same model modification can be transparently used with many
# other analysis functions, including [`flux_variability_analysis`](@ref) and
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8 changes: 4 additions & 4 deletions docs/src/examples/12_mmdf.jl
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# Here, we use the max-min driving force analysis (MMDF) to find optimal
# concentrations for the metabolites in glycolysis to ensure that the smallest
# driving force across all the reactions in the model is as large as possible.
# The method is described in more detail by Flamholz, Avi, et al., in
# "Glycolytic strategy as a tradeoff between energy yield and protein cost.",
# Proceedings of the National Academy of Sciences 110.24, 2013, 10039-10044
# (https://doi.org/10.1073/pnas.1215283110).
# The method is described in more detail by [Flamholz, et al., "Glycolytic
# strategy as a tradeoff between energy yield and protein cost.", Proceedings of
# the National Academy of Sciences,
# 2013](https://doi.org/10.1073/pnas.1215283110).

# We start as usual, with loading models and packages:

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7 changes: 3 additions & 4 deletions docs/src/examples/13_moma.jl
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# as a gene knockout) that prevents it from metabolizing optimally, but the
# rest of the metabolism has not yet adjusted to compensate for the change.

# The original description of MOMA is by: Segre, D., Vitkup, D., & Church, G. M.
# (2002). Analysis of optimality in natural and perturbed metabolic networks.
# *Proceedings of the National Academy of Sciences*, 99(23), 15112-15117
# (https://doi.org/10.1073/pnas.232349399).
# The original description of MOMA is by [Segre, Vitkup, and Church, "Analysis
# of optimality in natural and perturbed metabolic networks", Proceedings of the
# National Academy of Sciences, 2002](https://doi.org/10.1073/pnas.232349399).

# As always, let's start with downloading a model.

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7 changes: 3 additions & 4 deletions docs/src/examples/14_smoment.jl
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# the cell to respect known enzymatic parameters and enzyme mass constraints
# measured by proteomics and other methods.
#
# The original description from sMOMENT is by: Bekiaris, P.S. and Klamt, S., (2020).
# "Automatic construction of metabolic models with enzyme constraints.",
# *BMC bioinformatics*, 21(1), pp.1-13.
# (https://doi.org/10.1186/s12859-019-3329-9)
# The original description from sMOMENT is by [Bekiaris, and Klamt, "Automatic
# construction of metabolic models with enzyme constraints.", BMC
# bioinformatics, 2020](https://doi.org/10.1186/s12859-019-3329-9)
#
# Let's load some packages:

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13 changes: 6 additions & 7 deletions docs/src/examples/15_gecko.jl
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@@ -1,14 +1,13 @@
# # GECKO

# GECKO algorithm can be used to easily adjust the metabolic activity within
# the cell to respect many known parameters, measured by proteomics and other
# GECKO algorithm can be used to easily adjust the metabolic activity within the
# cell to respect many known parameters, measured by proteomics and other
# methods.
#
# The original description from GECKO is by: Sánchez, B.J., Zhang, C., Nilsson,
# A., Lahtvee, P.J., Kerkhoven, E.J. and Nielsen, J., (2017). "Improving the
# phenotype predictions of a yeast genome‐scale metabolic model by
# incorporating enzymatic constraints." *Molecular systems biology*, 13(8),
# p.935 (https://doi.org/10.15252/msb.20167411).
# The original description from GECKO is by: [Sánchez, et. al., "Improving the
# phenotype predictions of a yeast genome‐scale metabolic model by incorporating
# enzymatic constraints.", Molecular systems biology,
# 2017](https://doi.org/10.15252/msb.20167411).
#
# The analysis method and implementation in COBREXA is similar to
# [sMOMENT](14_smoment.md), but GECKO is able to process and represent much
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